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Chemerin Antikörper (AA 1-35)

Der Kaninchen Polyklonal Anti-Chemerin-Antikörper wurde für WB, IF und FACS validiert. Er ist geeignet, Chemerin in Proben von Human zu detektieren.
Produktnummer ABIN6243636

Kurzübersicht für Chemerin Antikörper (AA 1-35) (ABIN6243636)

Target

Alle Chemerin (RARRES2) Antikörper anzeigen
Chemerin (RARRES2) (Retinoic Acid Receptor Responder (Tazarotene Induced) 2 (RARRES2))

Reaktivität

  • 35
  • 35
  • 23
  • 15
Human

Wirt

  • 47
  • 7
  • 5
Kaninchen

Klonalität

  • 49
  • 10
Polyklonal

Konjugat

  • 23
  • 5
  • 4
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
Dieser Chemerin Antikörper ist unkonjugiert

Applikation

  • 50
  • 26
  • 26
  • 19
  • 8
  • 6
  • 6
  • 4
  • 3
  • 2
  • 2
  • 2
  • 1
Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Klon

RB56708
  • Bindungsspezifität

    • 15
    • 15
    • 7
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    AA 1-35

    Aufreinigung

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    Immunogen

    This RARRES2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 01-35 amino acids from human RARRES2.

    Isotyp

    Ig Fraction
  • Applikationshinweise

    IF: 1:25. WB: 1:2000. FC: 1:25

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Haltbarkeit

    6 months
  • Target

    Chemerin (RARRES2) (Retinoic Acid Receptor Responder (Tazarotene Induced) 2 (RARRES2))

    Andere Bezeichnung

    RARRES2

    Hintergrund

    Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). Its other ligands include G protein-coupled receptor 1 (GPR1) and chemokine receptor-like 2 (CCRL2). Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a proinflammatory adipokine, causing an increase in secretion of proinflammatory and prodiabetic adipokines, which further impair adipose tissue metabolic function and have negative systemic effects including impaired insulin sensitivity, altered glucose and lipid metabolism, and a decrease in vascular function in other tissues. Can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases. Acts as a chemotactic factor for leukocyte populations expressing CMKLR1, particularly immature plasmacytoid dendritic cells, but also immature myeloid DCs, macrophages and natural killer cells. Exerts an anti-inflammatory role by preventing TNF/TNFA-induced VCAM1 expression and monocytes adhesion in vascular endothelial cells. The effect is mediated via inhibiting activation of NF-kappa-B and CRK/p38 through stimulation of AKT1/NOS3 signaling and nitric oxide production. Its dual role in inflammation and metabolism might provide a link between chronic inflammation and obesity, as well as obesity- related disorders such as type 2 diabetes and cardiovascular disease. Exhibits an antimicrobial function in the skin.

    Molekulargewicht

    18618

    UniProt

    Q99969

    Pathways

    Brown Fat Cell Differentiation
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