Chemerin Antikörper (AA 101-163)

Produktnummer ABIN1715135

Es sind 3+ Publikationen für dieses Produkt verfügbar. Der Kaninchen Polyklonal anti-Chemerin Antikörper wird verwendet zum Nachweis von Chemerin in Proben von Ratte. Er wurde validiert für WB, IF (cc), IF (p), IHC (fro) und IHC (p).

Kurzübersicht für Chemerin Antikörper (AA 101-163) (ABIN1715135)

Target: Chemerin (RARRES2) (Retinoic Acid Receptor Responder (Tazarotene Induced) 2 (RARRES2))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Chemerin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-Chemerin Antikörper

Bindungsspezifität: AA 101-163

Verwendungszweck: Chemerin Polyclonal Antibody

Kreuzreaktivität: Human, Maus, Kaninchen, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from rat chemerin

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB(1:300-5000),

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-Chemerin Antikörper (ABIN1715135)

Gonzalvo-Feo, Del Prete, Pruenster, Salvi, Wang, Sironi, Bierschenk, Sperandio, Vecchi, Sozzani: "Endothelial cell-derived chemerin promotes dendritic cell transmigration." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 192, Issue 5, pp. 2366-73, (2014) (PubMed).

Akamata, Asano, Taniguchi, Yamashita, Saigusa, Nakamura, Noda, Aozasa, Toyama, Takahashi, Ichimura, Sumida, Tada, Sugaya, Kadono, Sato: "Increased expression of chemerin in endothelial cells due to Fli1 deficiency may contribute to the development of digital ulcers in systemic sclerosis." in: Rheumatology (Oxford, England), (2014) (PubMed).

Krautbauer, Wanninger, Eisinger, Hader, Beck, Kopp, Schmid, Weiss, Dorn, Buechler: "Chemerin is highly expressed in hepatocytes and is induced in non-alcoholic steatohepatitis liver." in: Experimental and molecular pathology, Vol. 95, Issue 2, pp. 199-205, (2013) (PubMed).

Details zu Chemerin

Target: Chemerin (RARRES2) (Retinoic Acid Receptor Responder (Tazarotene Induced) 2 (RARRES2))

Andere Bezeichnung: Chemerin

Hintergrund:

Synonyms: Rarres2, TIG2, tazarotene induced gene 2, Retinoic acid receptor responder protein 2, Tazarotene-induced gene 2 protein, RAR-responsive protein TIG2, Chemerin.

Background: Chemerin, also known as retinoic acid receptor responder 2 (RARRES2) and tazarotene induced gene 2 (TIG2), is a chemoattractant protein for cells expressing G-protein-linked receptor chemokine-like receptor 1 (CMKLR1, ChemR23 or GPCR-DEZ). The protein is synthesized as a secreted precursor, prochemerin (18 kDa), which is poorly active. Upon proteolytic removal of the last six amino acids, prochemerin is converted into mature active chemerin (15-16 kDa) that acts as a strong and highly specific agonist of its receptor CMKLR1. Chemerin is a newly described adipokine with effects on adipocyte differnetiation and metabolism.

Gen-ID: 297073

Pathways: Brown Fat Cell Differentiation