MAPT Antikörper (C-Term)
Kurzübersicht für MAPT Antikörper (C-Term) (ABIN6243259)
Target
Alle MAPT Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Bindungsspezifität
- AA 694-728, C-Term
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Homologie
- B
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Aufreinigung
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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Immunogen
- This MAPT antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 694-728 amino acids from the C-terminal region of human MAPT.
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Isotyp
- Ig Fraction
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Applikationshinweise
- WB: 1:1000. WB: 1:500
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C,-20 °C
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Haltbarkeit
- 6 months
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- MAPT (Microtubule-Associated Protein tau (MAPT))
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Andere Bezeichnung
- MAPT
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Hintergrund
- Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
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Molekulargewicht
- 78928
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UniProt
- P10636
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Pathways
- MAPK Signalweg, Microtubule Dynamics, M Phase, Regulation of Cell Size
Target
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