MME Antikörper (AA 472-505)

Produktnummer ABIN6243087

Der Maus Monoklonal anti-MME Antikörper wird verwendet zum Nachweis von MME in Proben von Human. Er wurde validiert für WB, FACS und IHC (p).

Kurzübersicht für MME Antikörper (AA 472-505) (ABIN6243087)

Target: MME (Membrane Metallo-Endopeptidase (MME))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MME Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: 965CT9-1-1

Produktdetails anti-MME Antikörper

Bindungsspezifität: AA 472-505

Aufreinigung: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This MME antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 472-505 amino acids from the Central region of human MME.

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: WB: 1:4000. IHC: 1:1000. IHC-P-Leica: 1:1000. FC: 1:25

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu MME

Target: MME (Membrane Metallo-Endopeptidase (MME))

Andere Bezeichnung: MME

Substanzklasse: Chemical

Hintergrund: Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:< a href="http://www.uniprot.org/citations/15283675" target="_blank">15283675, PubMed:< a href="http://www.uniprot.org/citations/8168535" target="_blank">8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:< a href="http://www.uniprot.org/citations/17101991" target="_blank">17101991). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:< a href="http://www.uniprot.org/citations/15283675" target="_blank">15283675). Involved in the degradation of atrial natriuretic factor (ANF) (PubMed:< a href="http://www.uniprot.org/citations/2531377" target="_blank">2531377, PubMed:< a href="http://www.uniprot.org/citations/2972276" target="_blank">2972276). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:< a href="http://www.uniprot.org/citations/20876573" target="_blank">20876573).

Molekulargewicht: 85514

UniProt: P08473

Pathways: RTK Signalweg, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Smooth Muscle Cell Migration