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MAP1LC3A Antikörper (AA 30-56)

MAP1LC3A Reaktivität: Human WB, IF, IHC (p) Wirt: Kaninchen Polyclonal RB11840 unconjugated
Produktnummer ABIN6243032
  • Target Alle MAP1LC3A Antikörper anzeigen
    MAP1LC3A (Microtubule-Associated Protein 1 Light Chain 3 alpha (MAP1LC3A))
    Bindungsspezifität
    • 23
    • 21
    • 20
    • 15
    • 13
    • 11
    • 11
    • 10
    • 10
    • 8
    • 8
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 30-56
    Reaktivität
    • 212
    • 106
    • 87
    • 12
    • 9
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 174
    • 44
    • 2
    Kaninchen
    Klonalität
    • 165
    • 55
    Polyklonal
    Konjugat
    • 109
    • 18
    • 15
    • 14
    • 14
    • 13
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Dieser MAP1LC3A Antikörper ist unkonjugiert
    Applikation
    • 198
    • 95
    • 74
    • 46
    • 33
    • 31
    • 29
    • 14
    • 14
    • 14
    • 11
    • 10
    • 9
    • 6
    • 5
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Homologie
    Zf, B, M, Rat
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This LC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 30-56 amino acids from human LC3.
    Klon
    RB11840
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product MAP1LC3A Primärantikörper
  • Applikationshinweise
    IF: 1:100. WB: 1:1000. IHC-P: 1:10~50
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Haltbarkeit
    6 months
  • Lu, Hsu: "Ambient temperature reduction extends lifespan via activating cellular degradation activity in an annual fish (Nothobranchius rachovii)." in: Age (Dordrecht, Netherlands), Vol. 37, Issue 2, pp. 33, (2015) (PubMed).

    Hsu, Chuang, Chan: "Changes in cellular degradation activity in young and old worker honeybees (Apis mellifera)." in: Experimental gerontology, Vol. 50, pp. 128-36, (2014) (PubMed).

  • Target
    MAP1LC3A (Microtubule-Associated Protein 1 Light Chain 3 alpha (MAP1LC3A))
    Andere Bezeichnung
    LC3 (MAP1LC3A Produkte)
    Synonyme
    ATG8E antikoerper, LC3 antikoerper, LC3A antikoerper, MAP1ALC3 antikoerper, MAP1BLC3 antikoerper, 1010001H21Rik antikoerper, 4922501H04Rik antikoerper, LC3a antikoerper, MGC69006 antikoerper, zgc:77094 antikoerper, MGC89867 antikoerper, MAP1LC3A antikoerper, map1lc3a antikoerper, microtubule associated protein 1 light chain 3 alpha antikoerper, microtubule-associated protein 1 light chain 3 alpha antikoerper, microtubule associated protein 1 light chain 3 alpha S homeolog antikoerper, MAP1LC3A antikoerper, Map1lc3a antikoerper, map1lc3a.S antikoerper, map1lc3a antikoerper
    Hintergrund
    Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. These proteins are involved in formation of autophagosomal vacuoles (autophagosomes). MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. MAP1LC3a is one of the light chain subunits and can associate with either MAP1A or MAP1B. The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II.
    NCBI Accession
    NP_115903, NP_852610
    UniProt
    Q9H492, Q9GZQ8
    Pathways
    Autophagie
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