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ATM Antikörper (N-Term)

Dieses Anti-ATM-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von ATM in WB und IHC (p). Geeignet für Human.
Produktnummer ABIN6242170

Kurzübersicht für ATM Antikörper (N-Term) (ABIN6242170)

Target

Alle ATM Antikörper anzeigen
ATM (Ataxia Telangiectasia Mutated (ATM))

Reaktivität

  • 163
  • 73
  • 32
  • 2
  • 1
  • 1
Human

Wirt

  • 133
  • 26
  • 5
  • 2
Kaninchen

Klonalität

  • 123
  • 43
Polyklonal

Konjugat

  • 89
  • 8
  • 7
  • 5
  • 5
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
Dieser ATM Antikörper ist unkonjugiert

Applikation

  • 77
  • 53
  • 43
  • 39
  • 28
  • 28
  • 27
  • 25
  • 22
  • 18
  • 8
  • 7
  • 4
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon

RB3111-3112
  • Bindungsspezifität

    • 34
    • 16
    • 15
    • 13
    • 7
    • 7
    • 7
    • 7
    • 7
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 5-34, N-Term

    Aufreinigung

    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

    Immunogen

    This ATM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 5~34 amino acids from the N-terminal region of human ATM.

    Isotyp

    Ig Fraction
  • Applikationshinweise

    WB: 1:500. IHC-P: 1:50~100

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Haltbarkeit

    6 months
  • Target

    ATM (Ataxia Telangiectasia Mutated (ATM))

    Andere Bezeichnung

    ATM

    Hintergrund

    ATM is involved in signal transduction, cell cycle control and DNA repair, and may function as a tumor suppressor. It is necessary for activation of ABL1 and SAPK, and phosphorylates p53, NFKBIA, BRCA1, CTIP, NIBRIN (NBS1), TERF1, and RAD9. This protein has potential roles in vesicle and/or protein transport, T-cell development, gonad and neurological function. ATM is also part of the BRCA1-associated genome surveillance complex. ATM is induced by ionizing radiation. Defects in ATM are the cause of ataxia talangiectasia (AT), also known as Louis-Bar syndrome, a rare recessive disorder characterized by progressive cerebellar ataxia, dilation of the blood vessels in the conjunctiva and eyeballs, immunodeficiency, growth retardation and sexual immaturity. About 30 % of AT patients develop lymphomas and leukemias. Defects in ATM also contribute to T-cell acute lymphoblastic leukemia (TALL) and T-prolymphocytic leukemia (TPLL). TPLL is characterized by a high white blood cell count, with a predominance of prolymphocytes, marked splenomegaly, lymphadenopathy, skin lesions and serous effusion. Defects in ATM also contribute to B-cell non-Hodgkin's lymphomas, and to B-cell chronic lymphocytic leukemia, a disease characterized by accumulation of mature CD5+ B lymphocytes, lymphadenopathy, immunodeficiency and bone marrow failure.

    Molekulargewicht

    350687

    NCBI Accession

    NP_000042

    UniProt

    Q13315

    Pathways

    p53 Signalweg, Apoptose, DNA Reparatur, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus
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