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beta Catenin Antikörper (pSer33, pSer37)

Name: beta Catenin Antikörper (pSer33, pSer37)
SKU: ABIN6241068
Price: 434.77 EUR
Availability: InStock

This anti-beta Catenin antibody (ABIN6241068) is a Rabbit Polyclonal antibody detecting beta Catenin in WB. Suitable for Human.

Western blot analysis of extracts from S cells, untreated or treated with Calyculin A, (100nM, 30 min), using Phospho-beta-catenin (Ser33/37) Antibody. (beta Catenin Antikörper (pSer33, pSer37))

1 image

(1 reference)

Produktnummer ABIN6241068

Datenblatt (PDF)

Kurzübersicht für beta Catenin Antikörper (pSer33, pSer37) (ABIN6241068)

Target

Alle beta Catenin (CATNB) Antikörper anzeigen

beta Catenin (CATNB) (Catenin, beta (CATNB))

Reaktivität

Human

Wirt

Kaninchen

Klonalität

Polyklonal

Konjugat

Dieser beta Catenin Antikörper ist unkonjugiert

Applikation

Western Blotting (WB)

Klon

RB42029

Discover our top product CATNB Primärantikörper

Bindungsspezifität
44

28

23

19

19

19

17

17

16

16

16

15

11

8

7

7

4

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 19-41, pSer33, pSer37

Homologie

B, Zf, M, Rat, X

Aufreinigung

This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen

This Phospho-beta-catenin (Ser33/37) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 19-41 amino acids from human beta-catenin .

Isotyp

Ig Fraction
anti-Catenin, beta (CATNB) (pSer33), (pSer37) antibody
CATNB Reaktivität: Human, Maus, Ratte WB, FACS, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) Wirt: Kaninchen Polyclonal unconjugated

anti-Catenin, beta (CATNB) (AA 661-781) antibody
CATNB Reaktivität: Human, Maus, Ratte, Schwein, Zebrafisch (Danio rerio) WB, FACS, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated

anti-Catenin, beta (CATNB) (C-Term) antibody
CATNB Reaktivität: Human, Maus, Ratte, Huhn, Rind (Kuh), Hund, Schwein, Kaninchen, Schaf, Affe, Hamster, Avian, Cat, Esel, Ziege, Meerschweinchen, Pferd WB, IF Wirt: Ziege Polyclonal unconjugated

anti-Catenin, beta (CATNB) (C-Term) antibody
CATNB Reaktivität: Human, Zebrafisch (Danio rerio) WB, IHC, ELISA Wirt: Kaninchen Polyclonal unconjugated

anti-Catenin, beta (CATNB) (pSer33), (pSer37), (pThr41) antibody
CATNB Reaktivität: Human, Maus, Ratte WB, IHC Wirt: Kaninchen Polyclonal unconjugated

anti-Catenin, beta (CATNB) (AA 439-675) antibody
CATNB Reaktivität: Human WB, IHC, IP, ICC Wirt: Kaninchen Polyclonal unconjugated

anti-Catenin, beta (CATNB) (AA 439-675) antibody
CATNB Reaktivität: Human WB, IHC, IP, ICC Wirt: Maus Monoclonal C11 unconjugated

anti-Catenin, beta (CATNB) antibody
CATNB Reaktivität: Human, Maus, Hamster WB, IP, ICC, ICFC Wirt: Maus Monoclonal EM-22 unconjugated

anti-Catenin, beta (CATNB) antibody
CATNB Reaktivität: Human, Maus, Ratte WB, IHC Wirt: Maus Monoclonal 4A3H3 unconjugated

anti-Catenin, beta (CATNB) (AA 764-781) antibody
CATNB Reaktivität: Human, Maus, Ratte WB, IHC (p), ICC, IHC (fro) Wirt: Kaninchen Polyclonal unconjugated

Applikationshinweise

WB: 1:1000

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Buffer

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

4 °C,-20 °C

Haltbarkeit

6 months
Zhuang, Wang, Wang, Ma, Han, Zou, Wu, Dong, Qu, Zang, Wu: "MicroRNA-23b functions as an oncogene and activates AKT/GSK3β/β-catenin signaling by targeting ST7L in hepatocellular carcinoma." in: Cell death & disease, Vol. 8, Issue 5, pp. e2804, (2018) (PubMed).
Target

beta Catenin (CATNB) (Catenin, beta (CATNB))

Andere Bezeichnung

beta-catenin

Hintergrund

Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:< a href="http://www.uniprot.org/citations/17524503" target="_blank">17524503, PubMed:< a href="http://www.uniprot.org/citations/18077326" target="_blank">18077326, PubMed:< a href="http://www.uniprot.org/citations/18086858" target="_blank">18086858, PubMed:< a href="http://www.uniprot.org/citations/18957423" target="_blank">18957423, PubMed:< a href="http://www.uniprot.org/citations/21262353" target="_blank">21262353, PubMed:< a href="http://www.uniprot.org/citations/22647378" target="_blank">22647378, PubMed:< a href="http://www.uniprot.org/citations/22699938" target="_blank">22699938, PubMed:< a href="http://www.uniprot.org/citations/22155184" target="_blank">22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity).

Molekulargewicht

85497

UniProt

P35222

Pathways

Peptide Hormone Metabolism