PTEN Antikörper (pSer385)

Produktnummer ABIN6241050

Der Kaninchen-Polyklonal Anti-PTEN-Antikörper wurde für DB validiert. Er ist geeignet zum Nachweis von PTEN in Proben aus Human. }

Kurzübersicht für PTEN Antikörper (pSer385) (ABIN6241050)

Target: PTEN (Phosphatase and Tensin Homolog (PTEN))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PTEN Antikörper ist unkonjugiert

Applikation: Dot Blot (DB)

Klon: RB39440

Produktdetails anti-PTEN Antikörper

Bindungsspezifität: pSer385

Homologie: M, X

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PTEN Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S385 of human PTEN.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: DB: 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu PTEN

Target: PTEN (Phosphatase and Tensin Homolog (PTEN))

Andere Bezeichnung: PTEN

Hintergrund: This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.

Molekulargewicht: 47166

NCBI Accession: NP_000305

UniProt: P60484

Pathways: T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Inositol Metabolic Process, Synaptic Membrane, Regulation of Cell Size, Autophagie, Platelet-derived growth Factor Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling