CD46 Antikörper (Biotin)

Produktnummer ABIN6187893

Dieses Maus Monoklonal-Antikörper erkennt spezifisch CD46 in FACS und IF. Er zeigt eine Reaktivität gegenüber Human und Pavian.

Kurzübersicht für CD46 Antikörper (Biotin) (ABIN6187893)

Target: CD46

Reaktivität: Human, Pavian

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD46 Antikörper ist konjugiert mit Biotin

Applikation: Flow Cytometry (FACS), Immunofluorescence (IF)

Klon: 169-1-E4-3

Produktdetails anti-CD46 Antikörper (Biotin)

Verwendungszweck: Mouse Monoclonal anti-CD46 (169-1-E4.3), Biotin Conjugate

Produktmerkmale: This antibody recognizes a protein of 52 kDa-58 kDa, identified as CD46 (also known as membrane cofactor protein, MCP). Its epitope is located on the four immunogenic short consensus repeat (SCR) domains at N-terminus of the protein. CD46 exists as many isoforms in a variety of tissues. It is strongly expressed on salivary gland ducts and kidney ducts, moderately on lymphocytes and endothelium, and weakly on interstitial tissues and muscle cells, but not on erythrocytes. CD46 functions as a C3b/C4b-binding glycoprotein that inhibits complement activation on host cells. It also serves as a measles virus receptor, an adherence factor for group A Streptococcus pyogenes, and a cellular pilus receptor for pathogenic Neisseria. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Stimulated human leukocytes

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: Does not react with horse, others not tested

• Immunofluorescence 0.5-1 μg/mL
• Flow Cytometry 0.5-1 μg/million cells/0.1 mL
• Optimal dilution for a specific application should be determined by user

Kommentare:

K562, U937, HL60, HeLa and Jurkat cells, and human lymphocytes. Lymph node and tonsil.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 100 μg/mL

Buffer: PBS/0.1 % BSA/0.05 % azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Details zu CD46

Target: CD46

Andere Bezeichnung: CD46

Hintergrund: AHUS2, Complement membrane cofactor protein, MCP, Measles virus receptor, Membrane cofactor protein, MIC10, TLX, Trophoblast leucocyte common antigen, Trophoblast lymphocyte cross reactive antigen

Molekulargewicht: 52-58 kDa

Gen-ID: 4179, 510402

UniProt: P15529

Pathways: Regulation of Actin Filament Polymerization