BAK1 Antikörper (N-Term)

Produktnummer ABIN615093

Der Kaninchen Polyklonal anti-BAK1 Antikörper (ABIN615093) detektiert spezifisch BAK1 in IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Hamster.

Kurzübersicht für BAK1 Antikörper (N-Term) (ABIN615093)

Target: BAK1 (BCL2-Antagonist/killer 1 (BAK1))

Reaktivität: Human, Maus, Hamster

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BAK1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-BAK1 Antikörper

Bindungsspezifität: N-Term

Spezifität: This antibody recognizes BCL2-antagonist/killer 1 (BAK1).

Aufreinigung: Immunoaffinity Chromatography

Immunogen: Synthetic peptide derived from N-terminal of Human Bcl-2-like 7. Genename: BAK1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 10 mM PBS, pH 7.4, 0.09 % Sodium Azide, 1 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C. DO NOT FREEZE!

Details zu BAK1

Target: BAK1 (BCL2-Antagonist/killer 1 (BAK1))

Andere Bezeichnung: Bcl-2-Like 7

Hintergrund: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bak, a pro-apoptotic Bcl-2 family member, is an oligomeric protein that localizes to the mitochondria. It is thought to share significant functional homology with Bax, another pro-apoptotic Bcl-2 family member, as disruption of bak or bax has little effect on cell death, but mice lacking both genes display multiple developmental defects and cells lacking bak and bax show decreased apoptotic capability.Synonyms: Apoptosis regulator BAK, BAK, BAK1, BCL2L7, Bcl-2 homologous antagonist/killer, Bcl-2-like protein 7, Bcl2-L-7, CDN1, cell death inhibitor 1

Gen-ID: 578

NCBI Accession: NP_001179

UniProt: Q16611

Pathways: Apoptose, Steroid Hormone Mediated Signaling Pathway, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response