SPTA1 Antikörper (AA 940-1160)

Produktnummer ABIN6148401

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch SPTA1 in WB, IHC und IF. Er zeigt eine Reaktivität gegenüber Human und wurde in 1 Publikation erwähnt.

Kurzübersicht für SPTA1 Antikörper (AA 940-1160) (ABIN6148401)

Target: SPTA1 (Spectrin alpha 1, Erythrocytic (SPTA1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SPTA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-SPTA1 Antikörper

Bindungsspezifität: AA 940-1160

Sequenz: KHEAFLLDLN SFGDSMKALR NQANACQQQQ AAPVEGVAGE QRVMALYDFQ ARSPREVTMK KGDVLTLLSS INKDWWKVEA ADHQGIVPAV YVRRLAHDEF PMLPQRRREE PGNITQRQEQ IENQYRSLLD RAEERRRRLL QRYNEFLLAY EAGDMLEWIQ EKKAENTGVE LDDVWELQKK FDEFQKDLNT NEPRLRDINK VADDLLFEGL LTPEGAQIRQ E

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 940-1160 of human alpha 1 Spectrin (NP_003117.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Referenzen für anti-SPTA1 Antikörper (ABIN6148401)

Talhouarne, Gall: "7SL RNA in vertebrate red blood cells." in: RNA (New York, N.Y.), Vol. 24, Issue 7, pp. 908-914, (2018) (PubMed).

Details zu SPTA1

Target: SPTA1 (Spectrin alpha 1, Erythrocytic (SPTA1))

Andere Bezeichnung: SPTA1

Hintergrund: Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia.,SPTA1,EL2,HPP,HS3,SPH3,SPTA,Signal Transduction,Cell Biology & Developmental Biology,Cytoskeleton,Microfilaments,Cardiovascular,Blood,Blood Cell Antigens,SPTA1

Molekulargewicht: 279 kDa/280 kDa

Gen-ID: 6708

UniProt: P02549

Pathways: Regulation of Actin Filament Polymerization