PSME4 Antikörper (AA 1634-1843)

Produktnummer ABIN6146359

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch PSME4 in WB und IHC. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für PSME4 Antikörper (AA 1634-1843) (ABIN6146359)

Target: PSME4 (Proteasome (Prosome, Macropain) Activator Subunit 4 (PSME4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PSME4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-PSME4 Antikörper

Bindungsspezifität: AA 1634-1843

Sequenz: LYPHQVPLVL QVLKQTARSS SWHARYTVLT YLQTMVFYNL FIFLNNEDAV KDIRWLVISL LEDEQLEVRE MAATTLSGLL QCNFLTMDSP MQIHFEQLCK TKLPKKRKRD PGSVGDTIPS AELVKRHAGV LGLGACVLSS PYDVPTWMPQ LLMNLSAHLN DPQPIEMTVK KTLSNFRRTH HDNWQEHKQQ FTDDQLLVLT DLLVSPCYYA

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1634-1843 of human PSME4 (NP_055429.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu PSME4

Target: PSME4 (Proteasome (Prosome, Macropain) Activator Subunit 4 (PSME4))

Andere Bezeichnung: PSME4

Hintergrund: Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.,PSME4,PA200,Cell Biology & Developmental Biology,Ubiquitin,PSME4

Molekulargewicht: 24 kDa/113 kDa/139 kDa/211 kDa

Gen-ID: 23198

UniProt: Q14997

Pathways: DNA Replication, Synthesis of DNA