PIAS4 Antikörper (AA 60-260)

Produktnummer ABIN6145602

Dieses Anti-PIAS4-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PIAS4 in WB. Geeignet für Human.

Kurzübersicht für PIAS4 Antikörper (AA 60-260) (ABIN6145602)

Target: PIAS4 (Protein Inhibitor of Activated STAT, 4 (PIAS4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PIAS4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PIAS4 Antikörper

Bindungsspezifität: AA 60-260

Sequenz: ELYETRYAKK NSEPAPQPHR PLDPLTMHST YDRAGAVPRT PLAGPNIDYP VLYGKYLNGL GRLPAKTLKP EVRLVKLPFF NMLDELLKPT ELVPQNNEKL QESPCIFALT PRQVELIRNS RELQPGVKAV QVVLRICYSD TSCPQEDQYP PNIAVKVNHS YCSVPGYYPS NKPGVEPKRP CRPINLTHLM YLSSATNRIT V

Kreuzreaktivität: Human, Maus

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 60-260 of human PIAS4 (NP_056981.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu PIAS4

Target: PIAS4 (Protein Inhibitor of Activated STAT, 4 (PIAS4))

Andere Bezeichnung: PIAS4

Hintergrund: Functions as an E3-type small ubiquitin-like modifier (SUMO ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation.,PIAS4,PIAS-gamma,PIASY,Piasg,ZMIZ6,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,Ubiquitin,Ubiquitin-Proteasome Signaling Pathway,Immunology & Inflammation,IL-6 Receptor Signaling Pathway,NF-kB Signaling Pathway,PIAS4

Molekulargewicht: 56 kDa

Gen-ID: 51588

UniProt: Q8N2W9

Pathways: JAK-STAT Signalweg, Interferon-gamma Pathway, Positive Regulation of Response to DNA Damage Stimulus