PIAS2 Antikörper (AA 483-572)

Produktnummer ABIN6145596

Dieses Anti-PIAS2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PIAS2 in WB und IHC. Geeignet für Human.

Kurzübersicht für PIAS2 Antikörper (AA 483-572) (ABIN6145596)

Target: PIAS2 (Protein Inhibitor of Activated STAT, 2 (PIAS2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PIAS2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-PIAS2 Antikörper

Bindungsspezifität: AA 483-572

Sequenz: DPPAKRKCIF MSETQSSPTK GVLMYQPSSV RVPSVTSVDP AAIPPSLTDY SVPFHHTPIS SMSSDLPGEQ RRNDINNELK LGTSSDTVQQ

Kreuzreaktivität: Human, Maus

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 483-572 of human PIAS2 (NP_775298.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu PIAS2

Target: PIAS2 (Protein Inhibitor of Activated STAT, 2 (PIAS2))

Andere Bezeichnung: PIAS2

Hintergrund: This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1.,PIAS2,ARIP3,DIP,MIZ,MIZ1,PIASX,PIASX-ALPHA,PIASX-BETA,SIZ2,ZMIZ4,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,Ubiquitin,Ubiquitin-Proteasome Signaling Pathway,Immunology & Inflammation,IL-6 Receptor Signaling Pathway,PIAS2

Molekulargewicht: 45 kDa/63 kDa/68 kDa

Gen-ID: 9063

UniProt: O75928

Pathways: JAK-STAT Signalweg, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling