VEGFR2/CD309 Antikörper (AA 20-200)

Produktnummer ABIN6142816

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch VEGFR2/CD309 in WB und IHC. Er zeigt eine Reaktivität gegenüber Human und wurde in 1 Publikation erwähnt.

Kurzübersicht für VEGFR2/CD309 Antikörper (AA 20-200) (ABIN6142816)

Highlights:

• High quality VEGFR2/CD309 Primärantikörper for the detection of VEGFR2.
• Reliable product with high standard validation data

Target: VEGFR2/CD309 (VEGFR2) (VEGF Receptor 2 (VEGFR2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser VEGFR2/CD309 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-VEGFR2/CD309 Antikörper

Bindungsspezifität: AA 20-200

Sequenz: ASVGLPSVSL DLPRLSIQKD ILTIKANTTL QITCRGQRDL DWLWPNNQSG SEQRVEVTEC SDGLFCKTLT IPKVIGNDTG AYKCFYRETD LASVIYVYVQ DYRSPFIASV SDQHGVVYIT ENKNKTVVIP CLGSISNLNV SLCARYPEKR FVPDGNRISW DSKKGFTIPS YMISYAGMVF C

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 20-200 of human VEGF Receptor 2 (NP_002244.1).

Isotyp: IgG

Produktspezifische Information:

What can the VEGFR2/CD309 Antibody ABIN6142816 be used for?: This polyclonal VEGFR2/CD309 Antibody detects VEGFR2/CD309. The VEGFR2/CD309 Antibody has been validated for various applications and can be used for the detection of VEGFR2/CD309 and derivatives by Western Blotting, Immunohistochemistry.

What validation data is available for this VEGFR2/CD309 Antibody?: The Primärantikörper is referenced in 1 publications and is characterized by a proven, very high reliability. It has currently 5 product images that show its performance in a variety of applications. The product is currently available in 20 μL, 100 μL, 500 μL, 1000 μL quantities. VEGFR2/CD309 Antibody for the detection of VEGFR2/CD309 and derivatives.

What is the function of VEGFR2/CD309?: Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009].

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Referenzen für anti-VEGFR2/CD309 Antikörper (ABIN6142816)

Ding, Shan, Nai, Lin, Zhou, Dong, Wu, Xiao, Zhou, Wang, Li, Fu, Lin, Jia, Dai, Bai: "DEPTOR Deficiency-Mediated mTORc1 Hyperactivation in Vascular Endothelial Cells Promotes Angiogenesis." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 46, Issue 2, pp. 520-531, (2018) (PubMed).

Details zu VEGFR2/CD309

Target: VEGFR2/CD309 (VEGFR2) (VEGF Receptor 2 (VEGFR2))

Andere Bezeichnung: KDR

Hintergrund: Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas.,CD309,FLK1,VEGFR,VEGFR2,VEGF Receptor 2,KDR,Cancer,Invasion and Metastasis,Signal Transduction,Kinase,Tyrosine kinases,Cell Biology & Developmental Biology,Growth factor,VEGF,VEGF Receptors,Endocrine & Metabolism,Immunology & Inflammation,CD markers,Stem Cells,Endothelial Progenitors,Hematopoietic Progenitors,Cardiovascular,Angiogenesis,Angiogenic growth factors,Hypoxia,KDR

Molekulargewicht: 75 kDa/79 kDa/151 kDa

Gen-ID: 3791

UniProt: P35968

Pathways: RTK Signalweg, Glycosaminoglycan Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2, Growth Factor Binding, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling