Cyclin D1 Antikörper (C-Term)

Produktnummer ABIN6138080

Dieses Anti-Cyclin D1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Cyclin D1 in WB, IHC, IF und IP. Geeignet für Human.

Kurzübersicht für Cyclin D1 Antikörper (C-Term) (ABIN6138080)

Target: Cyclin D1 (CCND1)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cyclin D1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Produktdetails anti-Cyclin D1 Antikörper

Bindungsspezifität: C-Term

Sequenz: PSMVAAGSVV AAVQGLNLRS PNNFLSYYRL TRFLSRVIKC DPDCLRACQE QIEALLESSL RQAQQNMDPK AAEEEEEEEE EVDLACTPTD VRDVDI

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human Cyclin D1 (NP_444284.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200,IP,1:50 - 1:100

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu Cyclin D1

Target: Cyclin D1 (CCND1)

Andere Bezeichnung: CCND1

Hintergrund: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.,BCL1,D11S287E,PRAD1,U21B31,CCND1,Cyclin D1,cyclin D1,Epigenetics & Nuclear Signaling,Cancer,Signal Transduction,PI3K-Akt Signaling Pathway,Cell Biology & Developmental Biology,Cell Cycle,Cyclins,G1/S Checkpoint,Hedgehog Signaling Pathway,CCND1

Molekulargewicht: 33 kDa

Gen-ID: 595

UniProt: P24385

Pathways: PI3K-Akt Signalweg, Zellzyklus, Mitotic G1-G1/S Phases, ER-Nucleus Signaling