Calmodulin 2 Antikörper (AA 1-149)

Produktnummer ABIN6137872

Dieser Anti-Calmodulin 2 Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von Calmodulin 2 in WB. Geeignet für Human.

Kurzübersicht für Calmodulin 2 Antikörper (AA 1-149) (ABIN6137872)

Target: Calmodulin 2 (CALM2)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Calmodulin 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Calmodulin 2 Antikörper

Bindungsspezifität: AA 1-149

Sequenz: MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ DMINEVDADG NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGY ISAAELRHVM TNLGEKLTDE EVDEMIREAD IDGDGQVNYE EFVQMMTAK

Kreuzreaktivität: Human, Maus

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-149 of human CALM2 (NP_001734.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu Calmodulin 2

Target: Calmodulin 2 (CALM2)

Andere Bezeichnung: CALM2

Hintergrund: This gene is a member of the calmodulin gene family. There are three distinct calmodulin genes dispersed throughout the genome that encode the identical protein, but differ at the nucleotide level. Calmodulin is a calcium binding protein that plays a role in signaling pathways, cell cycle progression and proliferation. Several infants with severe forms of long-QT syndrome (LQTS) who displayed life-threatening ventricular arrhythmias together with delayed neurodevelopment and epilepsy were found to have mutations in either this gene or another member of the calmodulin gene family (PMID:23388215). Mutations in this gene have also been identified in patients with less severe forms of LQTS (PMID:24917665), while mutations in another calmodulin gene family member have been associated with catecholaminergic polymorphic ventricular tachycardia (CPVT)(PMID:23040497), a rare disorder thought to be the cause of a significant fraction of sudden cardiac deaths in young individuals. Pseudogenes of this gene are found on chromosomes 10, 13, and 17. Alternative splicing results in multiple transcript variants encoding different isoforms.,CALM2,CAMII,LQT15,PHKD,PHKD2,caM,Signal Transduction,Kinase,ErbB-HER Signaling Pathway,Cell Biology & Developmental Biology,Cell Cycle,Centrosome,Cytoskeleton,Actins,Immunology & Inflammation,B Cell Receptor Signaling Pathway,T Cell Receptor Signaling Pathway,Neuroscience,Neurodegenerative Diseases,CALM2

Molekulargewicht: 17 kDa

Gen-ID: 805

UniProt: P62158

Pathways: RTK Signalweg, Interferon-gamma Pathway, Fc-epsilon Rezeptor Signalübertragung, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Cellular Glucan Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, G-protein mediated Events, Signaling Events mediated by VEGFR1 and VEGFR2, Interaction of EGFR with phospholipase C-gamma, Phototransduction, Negative Regulation of Transporter Activity, VEGFR1 Specific Signals, BCR Signaling