ATM Antikörper (AA 1900-2000)

Produktnummer ABIN6137281

Dieses Anti-ATM-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von ATM in WB. Geeignet für Human. Dieses Primary Antibody wurde in 1 Publikation zitiert.

Kurzübersicht für ATM Antikörper (AA 1900-2000) (ABIN6137281)

Target: ATM (Ataxia Telangiectasia Mutated (ATM))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATM Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-ATM Antikörper

Bindungsspezifität: AA 1900-2000

Sequenz: CLDKKSQRTM LAVVDYMRRQ KRPSSGTIFN DAFWLDLNYL EVAKVAQSCA AHFTALLYAE IYADKKSMDD QEKRSLAFEE GSQSTTISSL SEKSKEETGI S

Kreuzreaktivität: Human

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1900-2000 of human ATM (NP_000042.3).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:1000

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Referenzen für anti-ATM Antikörper (ABIN6137281)

Peng, Qi, Miao, Ren: "1,2:5,6-dianhydrogalactitol inhibits human glioma cell growth in vivo and in vitro by arresting the cell cycle at G2/M phase." in: Acta pharmacologica Sinica, Vol. 38, Issue 4, pp. 561-570, (2017) (PubMed).

Details zu ATM

Target: ATM (Ataxia Telangiectasia Mutated (ATM))

Andere Bezeichnung: ATM

Hintergrund: The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates, thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.,AT1,ATA,ATC,ATD,ATDC,ATE,TEL1,TELO1,ATM,Epigenetics & Nuclear Signaling,Chromatin Modifying Enzymes,Phosphorylation,DNA Damage & Repair,Cancer,Tumor suppressors,Signal Transduction,Kinase,Serine/threonine kinases,Cell Biology & Developmental Biology,Apoptosis,Mitochondrial Control of Apoptosis,Cell Cycle,G1/S Checkpoint,G2/M DNA Damage Checkpoint,Immunology & Inflammation,NF-kB Signaling Pathway,ATM

Molekulargewicht: 350 kDa

Gen-ID: 472

UniProt: Q13315

Pathways: p53 Signalweg, Apoptose, DNA Reparatur, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus