CTLA4 Antikörper

Produktnummer ABIN610404

Produktdetails anti-CTLA4 Antikörper

Target: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Fragment: Fab fragment

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CTLA4 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), ELISA, Functional Studies (Func)

Spezifität: CTLA-4 expressed on activated T cells.

Aufreinigung: Gel filtration

Sterilität: 0.1 μm filtered

Immunogen: Stimulated human PBL’,s and human CD152 Ig fusion protein.

Type of Immunogen: Fusion protein

Klon: ANC152-2-8H5

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Approved: ELISA, Flo, Func

Usage: Function: ANC152.2 blocks binding of CD152 (CTLA-4) Ig fusion protein to its CD80/CD86 receptor, and has been reported to modulate suppressive function of human T Regulatory Cells in Vitro. ANC152.2 can bind to intracellular CD152 in fixed permeabolized cells. The F(ab')2 form has been used to inhibit proliferation of activated T cells in vitro in a cholera toxin model. The applications listed have been tested for the unmodified form of this product. Other forms have not been tested.

Kommentare:

Target Species of Antibody: Human

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: 50 mM sodium phosphate,  pH 7.5, 100 mM potassium chloride, 150 mM sodium chloride. Product was 0.1 μm filtered, vialed under aseptic conditions. No preservative added

Konservierungsmittel: Without preservative

Handhabung: Do not freeze. Open under aseptic conditions.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 4°C. Do not freeze. Open under aseptic conditions.

Referenzen für anti-CTLA4 Antikörper (ABIN610404)

Zundel, Swiersz, Giaccia: "Caveolin 1-mediated regulation of receptor tyrosine kinase-associated phosphatidylinositol 3-kinase activity by ceramide." in: Molecular and cellular biology, Vol. 20, Issue 5, pp. 1507-14, (2000) (PubMed).

Chitaev, Troyanovsky: "Adhesive but not lateral E-cadherin complexes require calcium and catenins for their formation." in: The Journal of cell biology, Vol. 142, Issue 3, pp. 837-46, (1998) (PubMed).

Behrens, Vakaet, Friis, Winterhager, Van Roy, Mareel, Birchmeier et al.: "Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC ..." in: The Journal of cell biology, Vol. 120, Issue 3, pp. 757-66, (1993) (PubMed).

Details zu CTLA4

Target: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Andere Bezeichnung: CTLA4 / CD152 (CTLA4 Produkte)

Hintergrund: Name/Gene ID: CTLA4

Synonyms: CTLA4, CD152, CELIAC3, CD152 antigen, CTLA-4, Celiac disease 3, IDDM12, GRD4, GSE, CD152 isoform

Gen-ID: 1493

UniProt: P16410

Pathways: Cancer Immune Checkpoints