BRCA1 Antikörper (Ser1423)

Produktnummer ABIN5959016

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch BRCA1 in WB, ELISA, IF und IHC (p). Es zeigt Reaktivität gegenüber Proben von Human und Ratte.

Kurzübersicht für BRCA1 Antikörper (Ser1423) (ABIN5959016)

Target: BRCA1 (Breast Cancer 1 (BRCA1))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BRCA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-BRCA1 Antikörper

Bindungsspezifität: Ser1423

Spezifität: BRCA 1,BRCA1,BRCA1 DNA repair associated,BRCA1/BRCA2 containing complex subunit 1,BRCA1/BRCA2-containing complex,subunit 1,BRCA1,BRCAI,BRCC 1,BRCC1,Breast and ovarian cancer susceptibility protein 1,Breast Cancer 1,Breast Cancer 1 Early Onset,Breast cancer type 1 susceptibility protein,BROVCA1,FANCS,IRIS,PNCA4,PPP1R53,Protein phosphatase 1 regulatory subunit 53,PSCP,RING finger protein 53,RNF53

Aufreinigung: Affinity purification

Immunogen: Synthesized peptide derived from human BRCA1 around the non-phosphorylation site of Ser1423.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:5000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol, pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu BRCA1

Target: BRCA1 (Breast Cancer 1 (BRCA1))

Andere Bezeichnung: BRCA1

Hintergrund: This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40 % of inherited breast cancers and more than 80 % of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.

Molekulargewicht: 208kDa

Gen-ID: 672

UniProt: P38398

Pathways: Zellzyklus, DNA Reparatur, Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Response to DNA Damage Stimulus