BRCA1 Antikörper (Ser1524)

Produktnummer ABIN5959015

Produktdetails anti-BRCA1 Antikörper

Target: BRCA1 (Breast Cancer 1 (BRCA1))

Bindungsspezifität: Ser1524

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BRCA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: BRCA 1,BRCA1,BRCA1 DNA repair associated,BRCA1/BRCA2 containing complex subunit 1,BRCA1/BRCA2-containing complex,subunit 1,BRCA1,BRCAI,BRCC 1,BRCC1,Breast and ovarian cancer susceptibility protein 1,Breast Cancer 1,Breast Cancer 1 Early Onset,Breast cancer type 1 susceptibility protein,BROVCA1,FANCS,IRIS,PNCA4,PPP1R53,Protein phosphatase 1 regulatory subunit 53,PSCP,RING finger protein 53,RNF53

Aufreinigung: Affinity purification

Immunogen: Synthesized peptide derived from human BRCA1 around the non-phosphorylation site of Ser1524.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:20000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol,  pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu BRCA1

Target: BRCA1 (Breast Cancer 1 (BRCA1))

Andere Bezeichnung: BRCA1 (BRCA1 Produkte)

Hintergrund: This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40 % of inherited breast cancers and more than 80 % of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.

Molekulargewicht: 208kDa

Gen-ID: 672

UniProt: P38398

Pathways: Zellzyklus, DNA Reparatur, Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Response to DNA Damage Stimulus