TERT Antikörper (Ser824)

Produktnummer ABIN5958627

Der Kaninchen Polyklonal Anti-TERT-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, TERT in Proben von Human zu detektieren.

Kurzübersicht für TERT Antikörper (Ser824) (ABIN5958627)

Target: TERT (Telomerase Reverse Transcriptase (TERT))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TERT Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-TERT Antikörper

Bindungsspezifität: Ser824

Spezifität: CMM9,DKCA2,DKCB4,EST2,HEST2,htert,hTRT,PFBMFT1,TCS1,Telomerase associated protein 2,Telomerase catalytic subunit,Telomerase reverse transcriptase,Telomerase-associated protein 2,Telomere Reverse Transcriptase,TERT,TERT,TP2,TRT

Aufreinigung: Affinity purification

Immunogen: Synthesized peptide derived from human TERT around the non-phosphorylation site of Ser824.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, ELISA 1:20000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol,  pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu TERT

Target: TERT (Telomerase Reverse Transcriptase (TERT))

Andere Bezeichnung: TERT

Hintergrund: Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified, the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.

Molekulargewicht: 127kDa

Gen-ID: 7015

UniProt: O14746

Pathways: Telomere Maintenance