RAD51 Antikörper (Tyr315)

Produktnummer ABIN5958191

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch RAD51 in WB, ELISA und IHC (p). Es zeigt Reaktivität gegenüber Proben von Human und Maus.

Kurzübersicht für RAD51 Antikörper (Tyr315) (ABIN5958191)

Target: RAD51 (DNA Repair Protein Homolog 1 (RAD51))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RAD51 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-RAD51 Antikörper

Bindungsspezifität: Tyr315

Spezifität: BRCA1/BRCA2 containing complex,subunit 5,BRCC 5,BRCC5,DNA repair protein RAD51 homolog 1,DNA repair protein rhp51,FANCR,hRAD51,HsRAD51,HsT16930,MRMV2,Rad 51,RAD51,RAD51 homolog (RecA homolog,E. coli) (S. cerevisiae),RAD51 homolog A,RAD51 homolog,RAD51 recombinase,RAD51,S. cerevisiae,homolog of,RAD51,RAD51A,RECA,RecA like protein,RecA,E. coli,homolog of,Recombination protein A

Aufreinigung: Affinity purification

Immunogen: Synthesized peptide derived from human Rad51 around the non-phosphorylation site of Tyr315.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:20000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol,  pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu RAD51

Target: RAD51 (DNA Repair Protein Homolog 1 (RAD51))

Andere Bezeichnung: Rad51

Hintergrund: The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, whicHuman, Mouseay be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht: 37kDa

Gen-ID: 5888

UniProt: Q06609

Pathways: DNA Reparatur