GRIA2 Antikörper (Ser880)

Produktnummer ABIN5956617

Der Kaninchen Polyklonal Anti-GRIA2-Antikörper wurde für WB, ELISA, IF und IHC (p) validiert. Er ist geeignet, GRIA2 in Proben von Human, Ratte und Maus zu detektieren.

Kurzübersicht für GRIA2 Antikörper (Ser880) (ABIN5956617)

Target: GRIA2 (Glutamate Receptor, Ionotropic, AMPA 2 (GRIA2))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GRIA2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-GRIA2 Antikörper

Bindungsspezifität: Ser880

Spezifität: AMPA 2,AMPA selective glutamate receptor 2,AMPA-selective glutamate receptor 2,AMPA2,GluA2,GLUR 2,GLUR B,GluR K2,GluR-2,GluR-B,GluR-K2,GLUR2,GLURB,Glutamate receptor 2,Glutamate receptor ionotropic AMPA 2,Glutamate receptor ionotropic,Gria2,GRIA2,HBGR2

Aufreinigung: Affinity purification

Immunogen: Synthesized peptide derived from human GluR-2 around the non-phosphorylation site of Ser880.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:20000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol,  pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu GRIA2

Target: GRIA2 (Glutamate Receptor, Ionotropic, AMPA 2 (GRIA2))

Andere Bezeichnung: GluR-2

Hintergrund: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG, Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene.

Molekulargewicht: 99kDa

Gen-ID: 2891

UniProt: P42262

Pathways: PI3K-Akt Signalweg