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GRIA2 Antikörper (C-Term)

GRIA2 Reaktivität: Human, Ratte, Maus WB, IHC, ELISA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6261987
  • Target Alle GRIA2 Antikörper anzeigen
    GRIA2 (Glutamate Receptor, Ionotropic, AMPA 2 (GRIA2))
    Bindungsspezifität
    • 30
    • 16
    • 7
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 96
    • 72
    • 67
    • 11
    • 10
    • 10
    • 5
    • 5
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Ratte, Maus
    Wirt
    • 94
    • 10
    Kaninchen
    Klonalität
    • 82
    • 22
    Polyklonal
    Konjugat
    • 52
    • 6
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Dieser GRIA2 Antikörper ist unkonjugiert
    Applikation
    • 80
    • 27
    • 27
    • 24
    • 23
    • 16
    • 15
    • 10
    • 8
    • 8
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA
    Spezifität
    GluR2 Antibody detects endogenous levels of total GluR2.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Chicken,Xenopus
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human GluR2, corresponding to a region within C-terminal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product GRIA2 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    GRIA2 (Glutamate Receptor, Ionotropic, AMPA 2 (GRIA2))
    Andere Bezeichnung
    GRIA2 (GRIA2 Produkte)
    Synonyme
    GLUR2 antikoerper, GLURB antikoerper, GluA2 antikoerper, GluR-K2 antikoerper, HBGR2 antikoerper, GluR-2 antikoerper, GluR-B antikoerper, Glur-2 antikoerper, Glur2 antikoerper, GluR2 antikoerper, gluR-B antikoerper, glur2a antikoerper, gria2.1 antikoerper, zfGRIA2[a] antikoerper, glur2 antikoerper, glutamate ionotropic receptor AMPA type subunit 2 antikoerper, glutamate receptor, ionotropic, AMPA 2 antikoerper, glutamate receptor, ionotropic, AMPA2 (alpha 2) antikoerper, glutamate receptor, ionotropic, AMPA 2a antikoerper, glutamate receptor, ionotropic, AMPA 2 S homeolog antikoerper, GRIA2 antikoerper, Gria2 antikoerper, gria2a antikoerper, gria2.S antikoerper
    Hintergrund

    Description: Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Through complex formation with NSG1, GRIP1 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).

    Gene: GRIA2

    Molekulargewicht
    99kDa
    Gen-ID
    2891
    UniProt
    P42262
    Pathways
    PI3K-Akt Signalweg
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