Integrin beta 2 Antikörper (PE)

Produktnummer ABIN576530

Der Ratte Monoklonal Anti-Integrin beta 2-Antikörper wurde für FACS, IHC, IP, IHC (fro) und BR validiert. Er ist geeignet, Integrin beta 2 in Proben von Human und Hund zu detektieren.

Kurzübersicht für Integrin beta 2 Antikörper (PE) (ABIN576530)

Target: Integrin beta 2 (ITGB2)

Reaktivität: Human, Hund

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser Integrin beta 2 Antikörper ist konjugiert mit PE

Applikation: Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Blocking Reagent (BR)

Produktdetails anti-Integrin beta 2 Antikörper (PE)

Spezifität: YFC118.3 was clustered at the Fourth International Workshop on Leucocyte Differentiation Antigen (code number N221) as recognizing the CD18 antigen. The CD18 antigen is an integral membrane glycoprotein of 95kD molecular weight - known as the b chain, of the LFA-1 complex. The CD18 antigen is non-covalently linked to CD11a, b, c molecules. The main cellular reactivity of antibody YFC 118.3 is a strong reactivity with Leucocytes (platelets negative). The CD18 Molecule is the receptor for ICAM-1 and is thus important for cell adhesion. YFC118.3 blocks homotypic adhesion and other lymphocyte functions which involve the LFA-1 antigen.

Aufreinigung: Protein G purified

Immunogen: Human neutrophils.

Type of Immunogen: Cells

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Approved: Block, Flo (1:1), IHC, IHC-Fr, IP

Usage: The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested. Flow Cytometry: Use 10 μL of the suggested working dilution to label 100 μL whole blood or 10^6 cells in 100 μL. Method sheets are available on request.

Kommentare:

Target Species of Antibody: Human

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Distilled Water.

Konzentration: Lot specific

Buffer: Lyophilized, PBS,  pH 7.2, 0.09 % sodium azide, 1 % BSA.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Details zu Integrin beta 2

Target: Integrin beta 2 (ITGB2)

Andere Bezeichnung: ITGB2 / MAC-1 / CD18

Hintergrund: Name/Gene ID: ITGB2
Family: Integrin

Synonyms: ITGB2, CD18 antigen, CD18, Integrin beta chain, beta 2, LCAMB, MAC-1, MFI7, MF17, Integrin beta-2, LAD, LFA-1

Gen-ID: 3689

UniProt: P05107

Pathways: NF-kappaB Signalweg, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation