ASIC3 Antikörper (AA 50-100)
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- Target Alle ASIC3 (ACCN3) Antikörper anzeigen
- ASIC3 (ACCN3) (Amiloride-Sensitive Cation Channel 3 (ACCN3))
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Bindungsspezifität
- AA 50-100
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Reaktivität
- Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser ASIC3 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC)
- Verwendungszweck
- Rabbit antibody to extracellular ASIC3 (50-100)
- Spezifität
- Specific for ASIC3.
- Kreuzreaktivität
- Maus, Ratte
- Kreuzreaktivität (Details)
- Other species not yet tested.
- Aufreinigung
- IgG
- Immunogen
- A synthetic peptide from AA 50-100 of rat ASIC3 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in mouse.
- Isotyp
- IgG
- Top Product
- Discover our top product ACCN3 Primärantikörper
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- Applikationshinweise
- IHC WB. A concentration of 10-50,micro,g,ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Reconstitute in 500 µl of sterile water. Centrifuge to remove any insoluble material.
- Handhabung
- Avoid freeze and thaw cycles.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- ASIC3 (ACCN3) (Amiloride-Sensitive Cation Channel 3 (ACCN3))
- Andere Bezeichnung
- ASIC3 (ACCN3 Produkte)
- Hintergrund
- FUNCTION: Cation channel with high affinity for sodium which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties. SUBUNIT: Homotetramer or heterotetramer with other ASIC proteins (Probable). Interacts with STOM and DLG4. Interacts with LIN7B MAGI1/BAIAP1 GOPC and ACCN1. SUBCELLULAR LOCATION: Cell membrane, Multi-pass membrane protein. Cytoplasm. Note: Cell surface expression may be stabilized by interaction with LIN7B and cytoplasmic retention by interaction with DLG4. In part cytoplasmic in cochlea cells. TISSUE SPECIFICITY: Expressed by sensory neurons. Strongly expressed in brain spinal chord lung lymph nodes kidney pituitary heart and testis. DEVELOPMENTAL STAGE: Expressed in fetal tissues expression increases in lung and kidney adult tissues.
- UniProt
- O35240
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