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ASIC3 Antikörper (AA 50-100)

ACCN3 Reaktivität: Ratte WB, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN571604
  • Target Alle ASIC3 (ACCN3) Antikörper anzeigen
    ASIC3 (ACCN3) (Amiloride-Sensitive Cation Channel 3 (ACCN3))
    Bindungsspezifität
    • 9
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 50-100
    Reaktivität
    • 30
    • 10
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Ratte
    Wirt
    • 32
    • 3
    • 1
    Kaninchen
    Klonalität
    • 36
    Polyklonal
    Konjugat
    • 21
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ASIC3 Antikörper ist unkonjugiert
    Applikation
    • 23
    • 18
    • 10
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Verwendungszweck
    Rabbit antibody to extracellular ASIC3 (50-100)
    Spezifität
    Specific for ASIC3.
    Kreuzreaktivität
    Maus, Ratte
    Kreuzreaktivität (Details)
    Other species not yet tested.
    Aufreinigung
    IgG
    Immunogen
    A synthetic peptide from AA 50-100 of rat ASIC3 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in mouse.
    Isotyp
    IgG
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  • Applikationshinweise
    IHC WB. A concentration of 10-50,micro,g,ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Reconstitute in 500 µl of sterile water. Centrifuge to remove any insoluble material.
    Handhabung
    Avoid freeze and thaw cycles.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
    Haltbarkeit
    12 months
  • Target
    ASIC3 (ACCN3) (Amiloride-Sensitive Cation Channel 3 (ACCN3))
    Andere Bezeichnung
    ASIC3 (ACCN3 Produkte)
    Hintergrund
    FUNCTION: Cation channel with high affinity for sodium which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties. SUBUNIT: Homotetramer or heterotetramer with other ASIC proteins (Probable). Interacts with STOM and DLG4. Interacts with LIN7B MAGI1/BAIAP1 GOPC and ACCN1. SUBCELLULAR LOCATION: Cell membrane, Multi-pass membrane protein. Cytoplasm. Note: Cell surface expression may be stabilized by interaction with LIN7B and cytoplasmic retention by interaction with DLG4. In part cytoplasmic in cochlea cells. TISSUE SPECIFICITY: Expressed by sensory neurons. Strongly expressed in brain spinal chord lung lymph nodes kidney pituitary heart and testis. DEVELOPMENTAL STAGE: Expressed in fetal tissues expression increases in lung and kidney adult tissues.
    UniProt
    O35240
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