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CD3 Antikörper

Der Maus Monoklonal Anti-CD3-Antikörper wurde für FACS und ICC validiert. Er ist geeignet, CD3 in Proben von Human zu detektieren.
Produktnummer ABIN5710579

Kurzübersicht für CD3 Antikörper (ABIN5710579)

Target

Alle CD3 Antikörper anzeigen
CD3

Reaktivität

  • 221
  • 106
  • 36
  • 20
  • 17
  • 10
  • 8
  • 8
  • 7
  • 7
  • 7
  • 3
  • 3
  • 2
  • 2
  • 2
Human

Wirt

  • 265
  • 60
  • 27
  • 11
  • 6
  • 2
Maus

Klonalität

  • 359
  • 6
  • 1
Monoklonal

Konjugat

  • 105
  • 41
  • 32
  • 25
  • 25
  • 13
  • 10
  • 9
  • 8
  • 8
  • 8
  • 6
  • 5
  • 5
  • 5
  • 5
  • 4
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser CD3 Antikörper ist unkonjugiert

Applikation

  • 320
  • 95
  • 62
  • 60
  • 47
  • 44
  • 42
  • 22
  • 19
  • 10
  • 8
  • 7
  • 7
  • 6
  • 5
  • 4
  • 4
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Flow Cytometry (FACS), Immunocytochemistry (ICC)

Klon

TB3
  • Verwendungszweck

    Anti-Hu CD3 Purified

    Spezifität

    The mouse monoclonal antibody TB3 recognizes an extracellular epitope on CD3 antigen of the TCR/CD3 complex on mature human T cells. This antibody has superior binding than the clone TB2.

    Kreuzreaktivität (Details)

    Human

    Aufreinigung

    Purified by protein-A affinity chromatography.

    Reinheit

    > 95 % (by SDS-PAGE)

    Isotyp

    IgG2b kappa
  • Applikationshinweise

    Flow cytometry: Recommended dilution: 1-4 μg/mL.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Konzentration

    1 mg/mL

    Buffer

    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C

    Informationen zur Lagerung

    Store at 2-8°C. Do not freeze.
  • Target

    CD3

    Andere Bezeichnung

    CD3

    Hintergrund

    CD3 antigen, epsilon polypeptide,CD3 complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82 % of normal peripheral blood lymphocytes, 65-85 % of thymocytes and Purkynje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases.,CD3E, T3E, TCRE

    Gen-ID

    916

    UniProt

    P07766

    Pathways

    T-Zell Rezeptor Signalweg, Ubiquitin Proteasome Pathway
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