CD3 Antikörper
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- Target Alle CD3 Antikörper anzeigen
- CD3
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser CD3 Antikörper ist unkonjugiert
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Applikation
- Flow Cytometry (FACS), Immunocytochemistry (ICC)
- Verwendungszweck
- Anti-Hu CD3 Purified
- Spezifität
- The mouse monoclonal antibody TB3 recognizes an extracellular epitope on CD3 antigen of the TCR/CD3 complex on mature human T cells. This antibody has superior binding than the clone TB2.
- Kreuzreaktivität (Details)
- Human
- Aufreinigung
- Purified by protein-A affinity chromatography.
- Reinheit
- > 95 % (by SDS-PAGE)
- Klon
- TB3
- Isotyp
- IgG2b kappa
- Top Product
- Discover our top product CD3 Primärantikörper
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anti-CD3 (CD3) antibody
CD3 Reaktivität: Human, Maus, Ratte IHC, IF, WB Wirt: Kaninchen Polyclonal unconjugated
anti-CD3 (CD3) antibodyCD3 Reaktivität: Human FACS, IP, MS Wirt: Maus Monoclonal MEM-57 unconjugated
anti-CD3 (CD3) antibodyCD3 Reaktivität: Human FACS, IP, Func, MS Wirt: Maus Monoclonal MEM-57 unconjugated
anti-CD3 (CD3) antibody (Biotin)CD3 Reaktivität: Human, Non-Human Primate FACS, IP, IHC (fro) Wirt: Maus Monoclonal UCHT1 Biotin
anti-CD3 (CD3) antibody (PerCP)CD3 Reaktivität: Human, Non-Human Primate FACS Wirt: Maus Monoclonal UCHT1 PerCP
anti-CD3 (CD3) antibody (PerCP)CD3 Reaktivität: Human FACS Wirt: Maus Monoclonal MEM-57 PerCP
anti-CD3 (CD3) antibody (Biotin)CD3 Reaktivität: Maus FACS, IP, IHC (fro), ICC Wirt: Hamster Monoclonal 145-2C11 Biotin
anti-CD3 (CD3) antibody (FITC)CD3 Reaktivität: Maus FACS Wirt: Hamster Monoclonal 145-2C11 FITC
anti-CD3 (CD3) antibodyCD3 Reaktivität: Maus FACS, IP, IHC (fro), Func, ICC Wirt: Hamster Monoclonal 145-2C11 unconjugated
anti-CD3 (CD3) antibodyCD3 Reaktivität: Human FACS, IHC (fro) Wirt: Maus Monoclonal OKT3 unconjugated
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- Applikationshinweise
- Flow cytometry: Recommended dilution: 1-4 μg/mL.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C
- Informationen zur Lagerung
- Store at 2-8°C. Do not freeze.
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- Target
- CD3
- Andere Bezeichnung
- CD3 (CD3 Produkte)
- Hintergrund
- CD3 antigen, epsilon polypeptide,CD3 complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82 % of normal peripheral blood lymphocytes, 65-85 % of thymocytes and Purkynje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases.,CD3E, T3E, TCRE
- Gen-ID
- 916
- UniProt
- P07766
- Pathways
- T-Zell Rezeptor Signalweg, Ubiquitin Proteasome Pathway
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