Rekombinanter CLIP Antikörper (AA 25-39)

Produktnummer ABIN5707527

Der Kaninchen Monoklonal anti-CLIP Antikörper wird verwendet zum Nachweis von CLIP in Proben von Human, Ratte und Maus. Er wurde validiert für IHC (p).

Kurzübersicht für Rekombinanter CLIP Antikörper (AA 25-39) (ABIN5707527)

Target: CLIP (Corticotropin-Like Intermediate Peptide (CLIP))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser CLIP Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: Carrier-free

Klon: CLIP-2040R

Produktdetails anti-CLIP Antikörper

Bindungsspezifität: AA 25-39

Verwendungszweck: Recombinant ACTH Antibody / CLIP (azide and preservative free)

Sequenz: NGAEDESAEA FPLEF

Aufreinigung: Protein A affinity chromatography

Immunogen: Amino acids 25-39 (NGAEDESAEAFPLEF) of Adrenocorticotropic hormone (CLIP sequence) were used as the immunogen for this ACTH antibody.

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: The optimal dilution of the recombinant ACTH antibody for each application should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the recombinant ACTH antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu CLIP

Target: CLIP (Corticotropin-Like Intermediate Peptide (CLIP))

Andere Bezeichnung: ACTH / CLIP

Hintergrund: ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This mAb is specific to CLIP (aa 17-39 of ACTH) and does not react with Synacthen (aa 1-24 of ACTH). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs). It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH.

UniProt: P01189