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CLIP Antikörper (AA 25-39)

CLIP Reaktivität: Human, Ratte, Maus IHC (p) Wirt: Kaninchen Monoclonal CLIP-2040R unconjugated
Produktnummer ABIN5707525
  • Target Alle CLIP Produkte
    CLIP (Corticotropin-Like Intermediate Peptide (CLIP))
    Bindungsspezifität
    • 4
    • 3
    • 2
    AA 25-39
    Reaktivität
    Human, Ratte, Maus
    Wirt
    • 7
    • 6
    Kaninchen
    Klonalität
    • 8
    • 5
    Monoklonal
    Konjugat
    • 11
    • 1
    • 1
    Dieser CLIP Antikörper ist unkonjugiert
    Applikation
    • 6
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    Purified
    Reinheit
    Protein A affinity chromatography
    Immunogen
    Amino acids 25-39 (NGAEDESAEAFPLEF) of Adrenocorticotropic hormone (CLIP sequence) were used as the immunogen for this ACTH antibody.
    Klon
    CLIP-2040R
    Isotyp
    IgG kappa
  • Applikationshinweise
    The optimal dilution of the recombinant ACTH antibody for each application should be determined by the researcher.

    1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT,Prediluted IHC only format : incubate for 30 min at RT (1)
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store the recombinant ACTH antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
  • Target
    CLIP (Corticotropin-Like Intermediate Peptide (CLIP))
    Andere Bezeichnung
    ACTH / CLIP (CLIP Produkte)
    Hintergrund
    ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This mAb is specific to CLIP (aa 17-39 of ACTH) and does not react with Synacthen (aa 1-24 of ACTH). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs). It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH.
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