VEGFA Antikörper (AA 27-232)

Produktnummer ABIN5699617

Dieser Kaninchen Polyklonal Antikörper erkennt spezifisch VEGFA in WB, IHC, ELISA, IP und IF. Er zeigt eine Reaktivität gegenüber Human, Ratte und Maus.

Kurzübersicht für VEGFA Antikörper (AA 27-232) (ABIN5699617)

Target: VEGFA (Vascular Endothelial Growth Factor A (VEGFA))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser VEGFA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP), Immunofluorescence (IF)

Produktdetails anti-VEGFA Antikörper

Bindungsspezifität: AA 27-232

Verwendungszweck: VEGFA antibody

Immunogen:

Immunogen sequence: 27-232aa

Immunogen: vascular endothelial growth factor A

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB :1:200-1:2000,IP:1:200-1:2000,IF:1:10-1:100,IHC:1:50-1:500

Kommentare:

PC-3 cells were subjected to SDS PAGE followed by western blot with FNab09391(VEGFA antibody) at dilution of 1:800

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu VEGFA

Target: VEGFA (Vascular Endothelial Growth Factor A (VEGFA))

Andere Bezeichnung: VEGFA

Hintergrund:

Synonyms: Vascular endothelial growth factor A, long form (L-VEGF)|Vascular permeability factor (VPF)|N-VEGF|VEGFA|VEGFA|VEGF

Background: VEGFA, also named as VEGF or VPF, belongs to the PDGF/VEGF growth factor family. It is a growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. VEGFA induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. It binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. Defects in VEGFA are a cause of susceptibility to microvascular complications of diabetes type 1(MVCD1). VEGFA has 13 isoforms with MW 16kd to 45kd. Some isoforms has homodimer form, such as VEGFA189(38kd), VEFGA110(34kd). VEGFA is a 34kd to 42kd, dimeric, disulfide-bound glycoprotein. VEGF-A exists in at least seven homodimeric isoforms. The monomers consist of 121, 145, 148, 165, 183, 189, or 206 amino acids(PMID:15602010).

Molekulargewicht: 23-27kDa,45kDa

UniProt: P15692

Pathways: RTK Signalweg, Glycosaminoglycan Metabolic Process, Regulation of Cell Size, Tube Formation, Signaling Events mediated by VEGFR1 and VEGFR2, Platelet-derived growth Factor Receptor Signaling, VEGFR1 Specific Signals, VEGF Signaling