DCTN3 Antikörper (Internal Region)

Produktnummer ABIN569634

Der Ziege Polyklonal anti-DCTN3 Antikörper (ABIN569634) detektiert spezifisch DCTN3 in WB und EIA. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Ratte, Maus, Rind (Kuh) und Hund.

Kurzübersicht für DCTN3 Antikörper (Internal Region) (ABIN569634)

Target: DCTN3 (Dctn3) (Dynactin 3 (p22) (Dctn3))

Reaktivität: Human, Ratte, Maus, Rind (Kuh), Hund

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser DCTN3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-DCTN3 Antikörper

Bindungsspezifität: Internal Region

Sequenz: C-QVALGNISSK RE

Spezifität: This antibody is expected to recognize both reported isoforms (NP_009165.1, NP_077324.1).

Kreuzreaktivität (Details): Species reactivity (expected):Canine (Dog), Bovine.
Species reactivity (tested):Human, Mouse, Rat.

Aufreinigung: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide with sequence from the internal region of the protein sequence according to NP_009165.1 and NP_077324.1. Genename: DCTN3

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3 with 0.02 % Sodium Azide and 0.5 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu DCTN3

Target: DCTN3 (Dctn3) (Dynactin 3 (p22) (Dctn3))

Andere Bezeichnung: Dynactin Subunit 3

Hintergrund: This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing of this gene generates 2 transcript variants. Transcript Variant: This variant contains an additional 97 nt within the 3' coding region, as compared to variant 1 resulting in a frame-shift. Isoform 2 encoded by this variant has a different, and 10 aa shorter C-terminus than isoform 1.Synonyms: DCTN22, DCTN3

Molekulargewicht: 19.5kDa (NP_077324.1).

Gen-ID: 11258

NCBI Accession: NP_009165

UniProt: O75935

Pathways: M Phase