14-3-3 sigma/SFN Antikörper (AA 1-248)

Produktnummer ABIN5693156

Produktdetails anti-14-3-3 sigma/SFN Antikörper

Target: 14-3-3 sigma/SFN (SFN) (Stratifin (SFN))

Bindungsspezifität: AA 1-248

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser 14-3-3 sigma/SFN Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Marke: Picoband™

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for 14-3-3 sigma detection. Tested with WB, Direct ELISA in Human,Mouse,Rat.

Immunogen: E. coli-derived human 14-3-3 sigma recombinant protein (Position: M1-S248).

Anwendungsinformationen

Applikationshinweise:

Recommended Detection Systems: Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot.

Application Details: Western blot, 0.1-0.5 μg/mL
Direct ELISA, 0.1-0.5 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.

Referenzen für anti-14-3-3 sigma/SFN Antikörper (ABIN5693156)

Yang, Cheung, Peng, He, Wu, Xie, Jiang, Huang, Chen, Lin, Kung: "Makorin-2 is a neurogenesis inhibitor downstream of phosphatidylinositol 3-kinase/Akt (PI3K/Akt) signal." in: The Journal of biological chemistry, Vol. 283, Issue 13, pp. 8486-95, (2008) (PubMed).

Details zu 14-3-3 sigma/SFN

Target: 14-3-3 sigma/SFN (SFN) (Stratifin (SFN))

Andere Bezeichnung: SFN (SFN Produkte)

Synonyme: YWHAS antikoerper, Er antikoerper, Mme1 antikoerper, Ywhas antikoerper, stratifin antikoerper, SFN antikoerper, Sfn antikoerper

Hintergrund:

Synonyms: 14-3-3 protein sigma, Epithelial cell marker protein 1, Stratifin, SFN, HME1

Tissue Specificity: Present mainly in tissues enriched in stratified squamous keratinizing epithelium.

Background: Stratifin(SFN), also known as 14-3-3 protein sigma, is strongly induced by gamma irradiation and other DNA-damaging agents. The induction of 14-3-3-sigma is mediated by a p53 -responsive element located 1.8 kb upstream of its transcription start site. The protein, called stratifin, was shown to be diffusely distributed in the cytoplasm and was present in cultured epithelial cells. It was most abundant in tissues enriched in stratified keratinizing epithelium.

UniProt: P31947

Pathways: p53 Signalweg, Myometrial Relaxation and Contraction