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TLR1 Antikörper (AA 350-404)

Der Kaninchen Polyklonal Anti-TLR1-Antikörper wurde für WB, IHC, ELISA, FACS, ICC und IHC (fro) validiert. Er ist geeignet, TLR1 in Proben von Human, Maus und Ratte zu detektieren.
Produktnummer ABIN5693146

Kurzübersicht für TLR1 Antikörper (AA 350-404) (ABIN5693146)

Target

Alle TLR1 Antikörper anzeigen
TLR1 (Toll-Like Receptor 1 (TLR1))

Reaktivität

  • 87
  • 43
  • 26
  • 3
  • 3
  • 1
Human, Maus, Ratte

Wirt

  • 79
  • 19
  • 2
Kaninchen

Klonalität

  • 82
  • 18
Polyklonal

Konjugat

  • 44
  • 13
  • 10
  • 6
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser TLR1 Antikörper ist unkonjugiert

Applikation

  • 72
  • 38
  • 34
  • 28
  • 20
  • 20
  • 13
  • 13
  • 11
  • 9
  • 6
  • 5
  • 2
  • 2
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • Bindungsspezifität

    • 16
    • 8
    • 8
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 350-404

    Verwendungszweck

    Anti-TLR1 Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins.

    Produktmerkmale

    Anti-TLR1 Antibody Picoband® (ABIN5693146). Tested in ELISA, Flow Cytometry, IHC, IHC-F, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Immunogen

    E. coli-derived human TLR1 recombinant protein (Position: F350-D404).

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.1-0.5 μg/mL
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL
    Immunohistochemistry (Frozen Section), 0.5-1 μg/mL
    Immunocytochemistry, 0.5-1 μg/mL
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells
    ELISA, 0.1-0.5 μg/mL
    1. Hart, B. E., Tapping, R. I. Differential trafficking of TLR1 I602S underlies host protection against pathogenic mycobacteria. J. Immun. 189: 5347-5355, 2012. 2. West, A. P., Brodsky, I. E., Rahner, C., Woo, D. K., Erdjument-Bromage, H., Tempst, P., Walsh, M. C., Choi, Y., Shadel, G. S., Ghosh, S. TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature 472: 476-480, 2011. 3. Xu, Y., Tao, X., Shen, B., Horng, T., Medzhitov, R., Manley, J. L., Tong, L. Structural basis for signal transduction by the Toll/interleukin-1 receptor domains. Nature 408: 111-115, 2000.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target

    TLR1 (Toll-Like Receptor 1 (TLR1))

    Andere Bezeichnung

    TLR1

    Hintergrund

    Synonyms: Toll-like receptor 1, Toll/interleukin-1 receptor-like protein, TIL, CD281, TLR1, KIAA0012

    Tissue Specificity: Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine.

    Background: Toll-like receptor 1 (TLR1), also called TIL or CD281 is a member of the Toll-like receptor family (TLR) of pattern recognition receptors of the innate immune system. This gene is mapped to 4p14 by fluorescence in situ hybridization. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene.

    Molekulargewicht

    90 kDa

    Gen-ID

    7096

    UniProt

    Q15399

    Pathways

    TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
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