DYRK1A Antikörper (AA 38-269)

Produktnummer ABIN5693108

Produktdetails anti-DYRK1A Antikörper

Target: DYRK1A (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A))

Bindungsspezifität: AA 38-269

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DYRK1A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Marke: Picoband™

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for DYRK1A detection. Tested with WB, Direct ELISA in Human,Mouse,Rat.

Immunogen: E. coli-derived human DYRK1A recombinant protein (Position: H38-M269).

Anwendungsinformationen

Applikationshinweise:

Recommended Detection Systems: Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).

Application Details: Western blot, 0.1-0.5 μg/mL
Direct ELISA, 0.1-0.5 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.

Details zu DYRK1A

Target: DYRK1A (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A))

Andere Bezeichnung: DYRK1A (DYRK1A Produkte)

Synonyme: DYRK1A antikoerper, dyrk antikoerper, dyrk1 antikoerper, hp86 antikoerper, mnb antikoerper, mnbh antikoerper, DYRK antikoerper, DYRK1 antikoerper, HP86 antikoerper, MNB antikoerper, MNBH antikoerper, MRD7 antikoerper, 2310043O08Rik antikoerper, D16Ertd272e antikoerper, D16Ertd493e antikoerper, Dyrk antikoerper, ENSMUSG00000074897 antikoerper, Gm10783 antikoerper, Mnbh antikoerper, Mp86 antikoerper, mmb antikoerper, PSK47 antikoerper, dual specificity tyrosine phosphorylation regulated kinase 1A antikoerper, dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A antikoerper, dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a antikoerper, dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A S homeolog antikoerper, DYRK1A antikoerper, dyrk1a antikoerper, Dyrk1a antikoerper, dyrk1a.S antikoerper

Hintergrund:

Synonyms: Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Tissue Specificity: Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney.

Background: Dual specificity tyrosine-phosphorylation-regulated kinase 1A is an enzyme that in humans is encoded by the DYRK1A gene. This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.

UniProt: Q13627

Pathways: Mitotic G1-G1/S Phases