DYRK1A Antikörper (C-Term)
Kurzübersicht für DYRK1A Antikörper (C-Term) (ABIN1881275)
Target
Alle DYRK1A Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Bindungsspezifität
- AA 718-745, C-Term
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Aufreinigung
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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Immunogen
- This Mouse Dyrk1a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 718-745 amino acids from the C-terminal region of mouse Dyrk1a.
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Isotyp
- Ig Fraction
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Applikationshinweise
- WB: 1:1000
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C,-20 °C
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Haltbarkeit
- 6 months
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: "Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells." in: The Journal of biological chemistry, Vol. 285, Issue 41, pp. 31895-906, (2010) (PubMed).
: "DYRK1A and glycogen synthase kinase 3beta, a dual-kinase mechanism directing proteasomal degradation of CRY2 for circadian timekeeping." in: Molecular and cellular biology, Vol. 30, Issue 7, pp. 1757-68, (2010) (PubMed).
: "DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1." in: The Journal of biological chemistry, Vol. 285, Issue 17, pp. 13223-32, (2010) (PubMed).
: "Negative feedback Inhibition of NFATc1 by DYRK1A regulates bone homeostasis." in: The Journal of biological chemistry, Vol. 284, Issue 48, pp. 33343-51, (2009) (PubMed).
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- DYRK1A (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A))
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Andere Bezeichnung
- Dyrk1a
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Hintergrund
- Dyrk1a may play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.
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Molekulargewicht
- 85494
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NCBI Accession
- NP_001106860, NP_031916
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UniProt
- Q61214
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Pathways
- Mitotic G1-G1/S Phases
Target
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