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Retinoblastoma Binding Protein 4 Antikörper (C-Term)

Dieses Maus Monoklonal-Antikörper erkennt spezifisch Retinoblastoma Binding Protein 4 in WB und IHC. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.
Produktnummer ABIN5692929

Kurzübersicht für Retinoblastoma Binding Protein 4 Antikörper (C-Term) (ABIN5692929)

Target

Alle Retinoblastoma Binding Protein 4 (RBBP4) Antikörper anzeigen
Retinoblastoma Binding Protein 4 (RBBP4)

Reaktivität

  • 53
  • 44
  • 40
  • 5
  • 4
  • 4
  • 4
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 1
Human, Maus, Ratte

Wirt

  • 60
  • 7
  • 2
Maus

Klonalität

  • 50
  • 19
Monoklonal

Konjugat

  • 33
  • 4
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Retinoblastoma Binding Protein 4 Antikörper ist unkonjugiert

Applikation

  • 30
  • 21
  • 18
  • 17
  • 14
  • 14
  • 10
  • 9
  • 7
  • 7
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC)

Klon

9F3
  • Bindungsspezifität

    • 15
    • 11
    • 7
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 395-425, C-Term

    Verwendungszweck

    Anti-RbAp48 RBBP4 Antibody Picoband® (monoclonal, 9F3)

    Sequenz

    EDNIMQVWQM AENIYNDEDP EGSVDPEGQG S

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins.

    Produktmerkmale

    Anti-RbAp48 RBBP4 Antibody Picoband® (monoclonal, 9F3) (ABIN5692929). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Immunogen

    A synthetic peptide corresponding to a sequence at the C-terminus of human RbAp48, identical to the related mouse sequence.

    Isotyp

    IgG1
  • Applikationshinweise

    Western blot, 0.1-0.5 μg/mL
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL
    1. "Entrez Gene: RBBP4 retinoblastoma-binding protein 4". 2. Barak O, Lazzaro MA, Lane WS, Speicher DW, Picketts DJ, Shiekhattar R (November 2003). "Isolation of human NURF: a regulator of Engrailed gene expression". EMBO J 22 (22): 6089-100. 3. Qian YW, Wang YC, Hollingsworth RE Jr, Jones D, Ling N, Lee EY (September 1993). "A retinoblastoma-binding protein related to a negative regulator of Ras in yeast". Nature 364 (6438): 648-52.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target

    Retinoblastoma Binding Protein 4 (RBBP4)

    Andere Bezeichnung

    RBBP4

    Hintergrund

    Synonyms: Histone-binding protein RBBP4, Chromatin assembly factor 1 subunit C, CAF-1 subunit C, Chromatin assembly factor I p48 subunit, CAF-I 48 kDa subunit, CAF-I p48, Nucleosome-remodeling factor subunit RBAP48, Retinoblastoma-binding protein 4, RBBP-4, Retinoblastoma-binding protein p48, RBBP4, RBAP48

    Background: Histone-binding protein RBBP4 (also known as RbAp48, or NURF55) is a protein that in humans is encoded by the RBBP4 gene. This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. And it is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind ly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene.

    Molekulargewicht

    55 kDa

    Gen-ID

    5928

    UniProt

    Q09028

    Pathways

    Zellzyklus, Mitotic G1-G1/S Phases, Stem Cell Maintenance, Chromatin Binding, Protein targeting to Nucleus
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