Bestrophin 1 Antikörper

Produktnummer ABIN5692801

Produktdetails anti-Bestrophin 1 Antikörper

Target: Bestrophin 1 (BEST1)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Bestrophin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Marke: Picoband™

Sequenz: RFIYRLALTE EQQLMFEKLT LYCD

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Bestrophin detection. Tested with WB, IHC-F, ICC, FCM in Human.

Immunogen: A synthetic peptide corresponding to a sequence of human Bestrophin (RFIYRLALTEEQQLMFEKLTLYCD).

Anwendungsinformationen

Applikationshinweise:

Recommended Detection Systems: Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(F) and ICC.

Application Details: Western blot, 0.1-0.5 μg/mL
Immunohistochemistry(Frozen Section), 0.5-1 μg/mL
Immunocytochemistry, 0.5-1 μg/mL
Flow Cytometry, 1-3 μg/1x10⁶ cells

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.

Details zu Bestrophin 1

Target: Bestrophin 1 (BEST1)

Andere Bezeichnung: BEST1 (BEST1 Produkte)

Synonyme: CG6264 antikoerper, Dbest antikoerper, Dmel\\CG6264 antikoerper, anon-WO0118547.380 antikoerper, best antikoerper, dBest1 antikoerper, dbest1 antikoerper, dmBest1 antikoerper, BEST1 antikoerper, VMD2 antikoerper, best-1 antikoerper, ARB antikoerper, BEST antikoerper, BMD antikoerper, RP50 antikoerper, TU15B antikoerper, Bmd antikoerper, Vmd2 antikoerper, mBest1 antikoerper, Bestrophin 1 antikoerper, bestrophin 1 antikoerper, Best1 antikoerper, BEST1 antikoerper, best1 antikoerper, Bm1_25500 antikoerper

Hintergrund:

Synonyms: Bestrophin-1, TU15B, Vitelliform macular dystrophy protein 2, BEST1, VMD2

Tissue Specificity: Predominantly expressed in the basolateral membrane of the retinal pigment epithelium.

Background: Bestrophin-1 (Best1) is a protein that, in humans, is encoded by the BEST1 gene. This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.

UniProt: O76090