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Bestrophin 1 Antikörper

Der Kaninchen Polyklonal Anti-Bestrophin 1-Antikörper wurde für WB, IHC, FACS und ICC validiert. Er ist geeignet, Bestrophin 1 in Proben von Human zu detektieren.
Produktnummer ABIN5692801

Kurzübersicht für Bestrophin 1 Antikörper (ABIN5692801)

Target

Alle Bestrophin 1 (BEST1) Antikörper anzeigen
Bestrophin 1 (BEST1)

Reaktivität

  • 23
  • 4
  • 3
  • 2
  • 2
  • 1
Human

Wirt

  • 21
  • 4
Kaninchen

Klonalität

  • 23
  • 2
Polyklonal

Konjugat

  • 16
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Bestrophin 1 Antikörper ist unkonjugiert

Applikation

  • 17
  • 8
  • 6
  • 5
  • 3
  • 2
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)
  • Verwendungszweck

    Anti-Bestrophin/BEST1 Antibody Picoband®

    Sequenz

    RFIYRLALTE EQQLMFEKLT LYCD

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins.

    Produktmerkmale

    Anti-Bestrophin/BEST1 Antibody Picoband® (ABIN5692801). Tested in Flow Cytometry, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Immunogen

    A synthetic peptide corresponding to a sequence at the N-terminus of human Bestrophin, which shares 62.5% amino acid (aa) sequence identity with mouse Bestrophin.

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.1-0.5 μg/mL
    Immunohistochemistry (Frozen Section), 0.5-1 μg/mL
    Immunocytochemistry, 0.5-1 μg/mL
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells
    1. "Entrez Gene: BEST1 bestrophin 1". 2. Johnson AA, Guziewicz KE, Lee CJ, Kalathur RC, Pulido JS, Marmorstein LY, Marmorstein AD (January 2017). "Bestrophin 1 and retinal disease". review. Progress in Retinal and Eye Research. 58: 45-69.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target

    Bestrophin 1 (BEST1)

    Andere Bezeichnung

    BEST1

    Hintergrund

    Synonyms: Bestrophin-1, TU15B, Vitelliform macular dystrophy protein 2, BEST1, VMD2

    Tissue Specificity: Predominantly expressed in the basolateral membrane of the retinal pigment epithelium.

    Background: Bestrophin-1 (Best1) is a protein that, in humans, is encoded by the BEST1 gene. This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.

    Molekulargewicht

    68 kDa

    Gen-ID

    7439

    UniProt

    O76090
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