GZMB Antikörper (AA 21-247)

Produktnummer ABIN5692783

Der Kaninchen-Polyklonal Anti-GZMB-Antikörper wurde für WB und ELISA validiert. Er ist geeignet zum Nachweis von GZMB in Proben aus Maus und Ratte. }

Kurzübersicht für GZMB Antikörper (AA 21-247) (ABIN5692783)

Target: GZMB (Granzyme B (GZMB))

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GZMB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-GZMB Antikörper

Bindungsspezifität: AA 21-247

Verwendungszweck: Anti-Granzyme B/Gzmb Antibody

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-Granzyme B/Gzmb Antibody (ABIN5692783). Tested in ELISA, WB applications. This antibody reacts with Mouse, Rat. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

Aufreinigung: Immunogen affinity purified.

Immunogen: E. coli-derived mouse Granzyme B recombinant protein (Position: I21-S247).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL
ELISA, 0.1-0.5 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu GZMB

Target: GZMB (Granzyme B (GZMB))

Andere Bezeichnung: Gzmb

Hintergrund:

Synonyms: Granzyme B (G,H), CTLA-1, Cytotoxic cell protease 1, CCP1, Fragmentin-2, Gzmb, Ctla-1, Ctla1

Tissue Specificity: Isoform A is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In adults highest expression in heart, liver, small intestine, prostate and ovary. Low level in lung and kidney. Isoform B is highly expressed in hypothalamus.

Background: Granzyme B is a serine protease that in humans is encoded by the GZMB gene. Granzyme B is expressed by cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. CTL and NK cells share the remarkable ability to recognize specific infected target cells. They are thought to protect their host by inducing apoptosis of cells that bear on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.

Molekulargewicht: 28 kDa

Gen-ID: 14939

UniProt: P04187

Pathways: Apoptose, Caspase Kaskade in der Apoptose