BTLA Antikörper

Produktnummer ABIN5690631

Dieses Ratte Monoklonal-Antikörper erkennt spezifisch BTLA in FACS, ELISA und Func. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für BTLA Antikörper (ABIN5690631)

Target: BTLA (B and T Lymphocyte Associated (BTLA))

Reaktivität: Human

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser BTLA Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), ELISA, Functional Studies (Func)

Klon: 6F4

Produktdetails anti-BTLA Antikörper

Spezifität: Recognizes human BTLA.

Reinheit: > 95% (SDS-PAGE)

Immunogen: Ectodomain of human BTLA fused to human IgG Fc.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry: (frozen sections).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. In PBS containing 10 % glycerol.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for at least 1 year after receipt when stored at -20°C.

Details zu BTLA

Target: BTLA (B and T Lymphocyte Associated (BTLA))

Andere Bezeichnung: BTLA

Hintergrund: B and T lymphocyte associated (BTLA) is an Ig domain superfamily protein with cytoplasmic immunoreceptor tyrosine-based inhibitory motifs. The herpes virus entry mediator (HVEM), a member of the TNF receptor (TNFR) superfamily, can act as a molecular switch that modulates T cell activation by propagating positive signals from the TNF-related ligand LIGHT (TNFR superfamily 14), or inhibitory signals through the Ig superfamily member BTLA. The binding site on HVEM for BTLA is conserved in the orphan TNF receptor UL144, present in human CMV. UL144 binds BTLA, but not LIGHT, and inhibits T cell proliferation, selectively mimicking the inhibitory cosignaling function of HVEM.

Gen-ID: 151888

NCBI Accession: NP_861445

UniProt: Q7Z6A9

Pathways: Cancer Immune Checkpoints