PINK1 Antikörper (AA 120-170)

Produktnummer ABIN5690101

Der Kaninchen Polyklonal anti-PINK1 Antikörper wird verwendet zum Nachweis von PINK1 in Proben von Human, Maus und Ratte. Er wurde validiert für WB, ELISA, IF und IHC (p).

Kurzübersicht für PINK1 Antikörper (AA 120-170) (ABIN5690101)

Target: PINK1 (PTEN Induced Putative Kinase 1 (PINK1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PINK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-PINK1 Antikörper

Bindungsspezifität: AA 120-170

Spezifität: PINK1 antibody is human, mouse and rat reactive. At least two isoforms are known to exist, this antibody will only detect the longer isoform. PINK1 antibody will detect the cleaved and uncleaved form of PINK1.

Aufreinigung: PINK1 antibody is affinity chromatography purified via peptide column.

Immunogen: PINK1 antibody was raised against a 16 amino acid peptide near the amino terminus of human PINK1.

The immunogen is located within amino acids 120 - 170 of PINK1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: PINK1 antibody can be used for detection of PINK1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PINK1 antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: PINK1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu PINK1

Target: PINK1 (PTEN Induced Putative Kinase 1 (PINK1))

Andere Bezeichnung: PINK1

Hintergrund: The PTEN-induced putative kinase 1 (PINK1) is a serine/threonine protein kinase that localizes to mitochondria and is thought to protect cells from stress-induced mitochondrial dysfunction (reviewed in 1). PINK1 recruits the E3 ubiquitin ligase Parkin to mitochondria to initiate mitophagy, an autophagic process that clears damaged mitochondria within a cell (2). PINK1 is cleaved by the mitochondrial protease PARL (3). Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease (4).

Molekulargewicht: Predicted: 55 kDa

Observed: 53 kDa

Gen-ID: 65018

NCBI Accession: NP_115785

UniProt: Q9BXM7

Pathways: Autophagie