NOX3 Antikörper (AA 110-160)

Produktnummer ABIN5690083

Der Kaninchen Polyklonal Anti-NOX3-Antikörper wurde für ELISA, WB, IHC (p) und IF validiert. Er ist geeignet, NOX3 in Proben von Human und Maus zu detektieren.

Kurzübersicht für NOX3 Antikörper (AA 110-160) (ABIN5690083)

Target: NOX3 (NADPH Oxidase 3 (NOX3))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NOX3 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Produktdetails anti-NOX3 Antikörper

Bindungsspezifität: AA 110-160

Spezifität: NOX3 antibody is human and mouse reactive. NOX3 is predicted to not cross-react with other NOX proteins.

Aufreinigung: NOX3 antibody is affinity chromatography purified via peptide column.

Immunogen: NOX3 antibody was raised against a 15 amino acid peptide near the amino terminus of human NOX3.

The immunogen is located within amino acids 110 - 160 of NOX3.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: NOX3 antibody can be used for detection of NOX3 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: NOX3 antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: NOX3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu NOX3

Target: NOX3 (NADPH Oxidase 3 (NOX3))

Andere Bezeichnung: NOX3

Hintergrund: The NOX family of NAPDH oxidases is comprised of seven transmembrane proteins that oxidize intracellular NAPDH/NADH, causing electron transport across the membrane and the reduction of molecular oxygen to superoxide (1). NOX3 is expressed predominantly in the inner ear and is involved in the biogenesis of otoconia/otolith (2,3). It has been suggested that NOX3 is activated by the Transient Receptor Potential Vanilloid 1 (TRPV1), and this activity causes increased levels of reactive oxygen species in the inner ear, which in turn leads to STAT1-mediated inflammation and hearing loss (4).

Molekulargewicht: Predicted: 62 kDa

Observed: 72 kDa

Gen-ID: 50508

NCBI Accession: NP_056533

UniProt: Q9HBY0