FGFR3 Antikörper (AA 630-680)

Produktnummer ABIN5689961

Dieses Anti-FGFR3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von FGFR3 in WB, ELISA, IF und IHC (p). Geeignet für Human, Maus und Ratte.

Kurzübersicht für FGFR3 Antikörper (AA 630-680) (ABIN5689961)

Target: FGFR3 (Fibroblast Growth Factor Receptor 3 (FGFR3))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FGFR3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-FGFR3 Antikörper

Bindungsspezifität: AA 630-680

Spezifität: FGFR3 antibody is human, mouse and rat reactive. At least three isoforms of FGFR3 are known to exist, this antibody will detect all three.

Aufreinigung: FGFR3 Antibody is affinity chromatography purified via peptide column.

Immunogen: FGFR3 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human FGFR3.

The immunogen is located within amino acids 630 - 680 of FGFR3.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FGF3 antibody can be used for detection of FGFR3 by Western blot at 1 - 2 μ,g/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: FGFR3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: FGFR3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu FGFR3

Target: FGFR3 (Fibroblast Growth Factor Receptor 3 (FGFR3))

Andere Bezeichnung: FGFR3

Hintergrund: FGFR3 Antibody: FGFR3 is a tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis (1). It is required for normal skeleton development and promotes apoptosis in chondrocytes and cancer cell proliferation. FGFR3 protein contains three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain (1,2). It is alternatively spliced to produce three isoforms that are expressed in brain, kidney and testis. Defects in FGFR3 are associated with several diseases, including achondroplasia and hypochondroplasia (3,4). Mutations in FGFR3 are also a cause of some bladder and cervical cancers (5).

Molekulargewicht: Predicted: 89 kDa

Observed: 9+2, 98 kDa

Gen-ID: 2261

NCBI Accession: NP_001156685

UniProt: P22607

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Stem Cell Maintenance, Growth Factor Binding