FGFR3 Antikörper (AA 39-138)

Produktnummer ABIN1679839

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch FGFR3 in WB, IHC und IF. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für FGFR3 Antikörper (AA 39-138) (ABIN1679839)

Target: FGFR3 (Fibroblast Growth Factor Receptor 3 (FGFR3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FGFR3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-FGFR3 Antikörper

Bindungsspezifität: AA 39-138

Sequenz: PGPEPGQQEQ LVFGSGDAVE LSCPPPGGGP MGPTVWVKDG TGLVPSERVL VGPQRLQVLN ASHEDSGAYS CRQRLTQRVL CHFSVRVTDA PSSGDDEDGE

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 39-138 of human FGFR3 (NP_000133.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:100,IF,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu FGFR3

Target: FGFR3 (Fibroblast Growth Factor Receptor 3 (FGFR3))

Andere Bezeichnung: FGFR3

Hintergrund: This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described.,ACH,CD333,CEK2,HSFGFR3EX,JTK4,FGFR3,Cancer,Signal Transduction,Kinase,Tyrosine kinases,Cell Biology & Developmental Biology,Growth factor,ESC Pluripotency and Differentiation,Immunology & Inflammation,CD markers,Stem Cells,Neural Stem Cells,Cardiovascular,Angiogenesis,FGFR3

Molekulargewicht: 75 kDa/85 kDa/87 kDa/88 kDa

Gen-ID: 2261

UniProt: P22607

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Stem Cell Maintenance, Growth Factor Binding