CISD2 Antikörper (AA 40-90)

Produktnummer ABIN5689926

Dieser Kaninchen Polyklonal Antikörper erkennt spezifisch CISD2 in WB, ELISA, IF und IHC (p). Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für CISD2 Antikörper (AA 40-90) (ABIN5689926)

Target: CISD2 (CDGSH Iron Sulfur Domain 2 (CISD2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CISD2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-CISD2 Antikörper

Bindungsspezifität: AA 40-90

Aufreinigung: CISD2 Antibody is affinity chromatography purified via peptide column.

Immunogen: CISD2 antibody was raised against a 15 amino acid peptide near the center of human CISD2.

The immunogen is located within amino acids 40 - 90 of CISD2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: CISD2 antibody was raised against a 15 amino acid peptide near the center of human CISD2.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: CISD2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: CISD2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu CISD2

Target: CISD2 (CDGSH Iron Sulfur Domain 2 (CISD2))

Andere Bezeichnung: CISD2

Hintergrund: CISD2 Antibody: Defects in the CISD2 (CDGSH iron sulfur domain 2) gene are a cause of the neurodegenerative disorder Wolfram syndrome 2. CISD2 is a zinc finger protein that localizes to the endoplasmic reticulum and mitochondria and binds an iron/sulfur cluster. CISD2 interacts with Bcl-2 and can be displaced by the BH3-only protein BIK and contributes to the regulation of BIK-initiated autophagy. CISD2 deficiency in mice causes mitochondrial breakdown accompanied by autophagic cell death as well as the development of premature aging phenotype.

Molekulargewicht: Predicted: 15 kDa

Observed: 15 kDa

Gen-ID: 493856

NCBI Accession: NP_001008389

UniProt: Q8N5K1

Pathways: Activation of Innate immune Response