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CDK4 Antikörper (AA 295-299)
CDK4
Reaktivität: Human
WB
Wirt: Kaninchen
Polyclonal
unconjugated
Produktnummer ABIN5689386
Produktdetails anti-CDK4 Antikörper
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Target
Alle CDK4 Antikörper anzeigen
CDK4
(Cyclin-Dependent Kinase 4 (CDK4))
Bindungsspezifität
Alle Epitope für CDK4 Antikörper
AA 295-299
Reaktivität
Alle Reaktivitäten für CDK4 Antikörper
Human
Wirt
Alle Wirte für CDK4 Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für CDK4 Antikörper
Polyklonal
Konjugat
Alle Konjugate für CDK4 Antikörper
Dieser CDK4 Antikörper ist unkonjugiert
Applikation
Alle Applikationen für CDK4 Antikörper
Western Blotting (WB)
Spezifität
This antibody detects endogenous levels of total CDK4 protein.
Aufreinigung
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Immunogen
CDK4 antibody was raised against a peptide sequence around aa.295~299 (L-H-K-D-E) derived from Human CDK4. .
Top Product
Discover our top product CDK4 Primärantikörper
Alternativen
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Anwendungsinformationen
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Applikationshinweise
Western Blot: 1:500~1:1000
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Format
Liquid
Konzentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
-20 °C
Informationen zur Lagerung
Store antibody at -20°C for up to one year.
Details zu CDK4
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Target
CDK4
(Cyclin-Dependent Kinase 4 (CDK4))
Andere Bezeichnung
CDK4 (CDK4 Produkte )
Synonyme
zgc:153726 antikoerper, CMM3 antikoerper, PSK-J3 antikoerper, Crk3 antikoerper, 8-6 antikoerper, CDK4 antikoerper, CDK4/6 antikoerper, CG5072 antikoerper, Cdk4/6 antikoerper, DmCdk4 antikoerper, Dmel\\CG5072 antikoerper, Pk53C antikoerper, Pk?7 antikoerper, cdk antikoerper, cdk4 antikoerper, cdk4/6 antikoerper, dCdk4 antikoerper, l(2)05428 antikoerper, l(2)0671 antikoerper, l(2)k06503 antikoerper, l(2)s4639 antikoerper, l(2)sh0671 antikoerper, xcdk4 antikoerper, cyclin-dependent kinase 4 antikoerper, cyclin dependent kinase 4 antikoerper, Cyclin-dependent kinase 4 antikoerper, cyclin-dependent kinase 4 L homeolog antikoerper, cdk4 antikoerper, CDK4 antikoerper, Cdk4 antikoerper, cdk4.L antikoerper
Hintergrund
Cyclin-dependent kinase activity is regulated by T-loop phosphorylation (Thr172 in the case of CDK4), by the abundance of their cyclin partners, and by association with CDK inhibitors of the Cip/Kip or INK family of proteins . The inactive ternary complex of CDK4/cyclin D and p27 Kip1/Cip1 requires extracellular mitogenic stimuli for the release and degradation of p27, which affects progression through the restriction point and pRb-dependent entry into S-phase . The active complex of CDK4/cyclin D targets the retinoblastoma protein for phosphorylation, allowing the release of E2F transcription factors that activate G1/S-phase gene expression . In HeLa cells, upon UV irradiation, upregulation of p16 INK4A association with CDK4/cyclin D3 leads to a G2 delay, implicating CDK4/cyclin D3 activity in progression through the G2-phase of the cell cycle .
Molekulargewicht
34 kDa
Gen-ID
1019
NCBI Accession
NP_000066
UniProt
P11802
Pathways
Zellzyklus , Mitotic G1-G1/S Phases , Regulation of Cell Size
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