TWIST1 Antikörper (AA 18-22)

Produktnummer ABIN5689354

Der Kaninchen Polyklonal Anti-TWIST1-Antikörper wurde für WB validiert. Er ist geeignet, TWIST1 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für TWIST1 Antikörper (AA 18-22) (ABIN5689354)

Target: TWIST1 (Twist Homolog 1 (Drosophila) (TWIST1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TWIST1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-TWIST1 Antikörper

Bindungsspezifität: AA 18-22

Spezifität: This antibody detects endogenous levels of total Twist1 protein.

Aufreinigung: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogen: Twist1 antibody was raised against a peptide sequence around aa.18~22 (S-N-S-E-E) derived from Human Twist1.

Anwendungsinformationen

Applikationshinweise: Western Blot: 1:500~1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store antibody at -20°C for up to one year.

Details zu TWIST1

Target: TWIST1 (Twist Homolog 1 (Drosophila) (TWIST1))

Andere Bezeichnung: Twist1

Hintergrund: Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation.

Molekulargewicht: 28 kDa

Gen-ID: 7291

NCBI Accession: NP_000465

UniProt: Q15672

Pathways: p53 Signalweg, Proton Transport, Tube Formation, Negative Regulation of Transporter Activity