POLD2 Antikörper

Produktnummer ABIN567777

Produktdetails anti-POLD2 Antikörper

Target: POLD2 (Polymerase (DNA Directed), delta 2, Accessory Subunit (POLD2))

Reaktivität: Human, Ratte, Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser POLD2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: This antibody reacts with DNA polymerase delta p50 small subunit (50 kDa) by Western blotting.

Aufreinigung: Protein-G Agarose Chromatography of hybridoma supernatant.

Immunogen: Recombinant full length His-Human p50

Klon: 7B4

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS, pH 7.2 containing 50 % Glycerol without preservatives.

Konservierungsmittel: Without preservative

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody (in aliquots) at -20 °C.

Details zu POLD2

Target: POLD2 (Polymerase (DNA Directed), delta 2, Accessory Subunit (POLD2))

Andere Bezeichnung: POLD2 (POLD2 Produkte)

Synonyme: 50kDa antikoerper, p50 antikoerper, po1D2 antikoerper, cdc1 antikoerper, si:dz150f13.3 antikoerper, zgc:55633 antikoerper, zgc:77043 antikoerper, DNA polymerase delta 2, accessory subunit antikoerper, polymerase (DNA directed), delta 2, regulatory subunit antikoerper, polymerase (DNA directed), delta 2, accessory subunit L homeolog antikoerper, POLD2 antikoerper, Pold2 antikoerper, pold2.L antikoerper, pold2 antikoerper

Hintergrund: In eukaryotic cells, 3 types of DNA polymerases (pol), pol alpha, pol delta and pol epsilon function in accurate and efficient DNA replication. Pol delta is a heteromultimeric enzyme composed of a 125 kDa major catalytic subunit and three smaller accessory subunits. Pol delta requires a number of accessory molecules to exert its full activity. Proliferating cell nuclear antigen (PCNA) forms a doughnut-shaped trimer with a 35 Ä hole and works as the sliding clamp and replication factor C acts as the clamp loader to improve Pol delta processivity. Pol delta is also involved in nucleotide excision repair of DNA.Synonyms: DNA polymerase delta subunit 2, DNA polymerase delta subunit p50

Gen-ID: 5425

NCBI Accession: NP_001120690

UniProt: P49005

Pathways: Telomere Maintenance, DNA Reparatur, DNA Replication, Synthesis of DNA