SMC6 Antikörper (N-Term)

Produktnummer ABIN5672641

Der Kaninchen Polyklonal anti-SMC6 Antikörper wird verwendet zum Nachweis von SMC6 in Proben von Human. Er wurde validiert für WB.

Kurzübersicht für SMC6 Antikörper (N-Term) (ABIN5672641)

Target: SMC6 (SMC6 Structural Maintenance of Chromosomes 6-Like 1 (SMC6))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SMC6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-SMC6 Antikörper

Bindungsspezifität: N-Term

Sequenz: NFSSPKNAKR PRQEELEDFD KDGDEDECKG TTLTAAEVGI IESIHLKNFM

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SMC6

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu SMC6

Target: SMC6 (SMC6 Structural Maintenance of Chromosomes 6-Like 1 (SMC6))

Andere Bezeichnung: SMC6

Hintergrund: Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome.

Alias Symbols: SMC-6, hSMC6, SMC6L1

Protein Size: 1091

Gen-ID: 79677

NCBI Accession: NM_001142286, NP_001135758

UniProt: Q96SB8